DNA methylation in cord blood in association with prenatal depressive symptoms

Prenatal symptoms of depression (PND) and anxiety affect up to every third pregnancy. Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic mechanisms together with other factors such as genetic and environmental. We investigated DN...

Full description

Saved in:
Bibliographic Details
Published in:Clinical epigenetics 2021-04, Vol.13 (1), p.78, Article 78
Main Authors: Kallak, Theodora Kunovac, Bränn, Emma, Fransson, Emma, Johansson, Åsa, Lager, Susanne, Comasco, Erika, Lyle, Robert, Skalkidou, Alkistis
Format: Article
Language:English
Subjects:
Adult
Analysis
Antidepressants
Anxiety
CBCL
Child psychopathology
Children
Comorbidity
Cord blood
CpG islands
Deoxyribonucleic acid
Depression, Mental
Depressive Disorder - genetics
Depressive Disorder - psychology
DNA
DNA methylation
DNA Methylation - genetics
EPDS
Epigenetic inheritance
Epigenetics
EWAS
Female
Fetal Blood
Genomes
Genomics
Glucocorticoids
Humans
Infant, Newborn
Investigations
Male
Mental depression
Mental disorders
Mental health
Methylation
Middle Aged
Mood
Morbidity
Mothers - psychology
Pregnancy
Pregnancy Complications - genetics
Pregnancy Complications - psychology
Pregnant women
Prenatal depressive symptoms
Prenatal Exposure Delayed Effects - genetics
Prenatal Exposure Delayed Effects - psychology
Serotonin uptake inhibitors
Women
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prenatal symptoms of depression (PND) and anxiety affect up to every third pregnancy. Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic mechanisms together with other factors such as genetic and environmental. We investigated DNA methylation in cord blood in relation to PND, taking into consideration a history of depression, co-morbidity with anxiety and selective serotonin reuptake inhibitors (SSRI) use, and stratified by sex of the child. Mothers (N = 373) prospectively filled out web-based questionnaires regarding mood symptoms and SSRI use throughout pregnancy. Cord blood was collected at birth and DNA methylation was measured using Illumina MethylationEPIC array at 850 000 CpG sites throughout the genome. Differentially methylated regions were identified using Kruskal-Wallis test, and Benjamini-Hochberg adjusted p-values 
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-021-01054-0