Blood-brain barrier targeted delivery of lacosamide-conjugated gold nanoparticles: Improving outcomes in absence seizures

Most currently available antiepileptics are not fully effective in the prevention of seizures in absence epilepsy owing to the presence of blood-brain barrier (BBB). We aimed to test whether binding an antiepileptic drug, lacosamide (LCM), to glucose-coated gold nanoparticles (GNPs) enables efficien...

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Bibliographic Details
Published in:Epilepsy research 2022-08, Vol.184, p.106939-106939, Article 106939
Main Authors: Temizyürek, Arzu, Yılmaz, Canan Uğur, Emik, Serkan, Akcan, Uğur, Atış, Müge, Orhan, Nurcan, Arıcan, Nadir, Ahishali, Bulent, Tüzün, Erdem, Küçük, Mutlu, Gürses, Candan, Kaya, Mehmet
Format: Article
Language:English
Subjects:
Absence epilepsy
Blood -brain barrier
Gold nanoparticles
Lacosamide
Spike -wave discharges
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Summary:Most currently available antiepileptics are not fully effective in the prevention of seizures in absence epilepsy owing to the presence of blood-brain barrier (BBB). We aimed to test whether binding an antiepileptic drug, lacosamide (LCM), to glucose-coated gold nanoparticles (GNPs) enables efficient brain drug delivery to suppress the epileptic activity in WAG/Rij rats with absence epilepsy. In these animals, intracranial-EEG recording, behavioral test, in vivo imaging of LCM and LCM-GNP conjugate distribution in the brain, inductively coupled plasma mass spectrometry analysis, immunofluorescence staining of glucose transporter (Glut)-1, glial fibrillary acidic protein (GFAP), and p-glycoprotein (P-gp) and electron microscopy were performed. Lacosamide-GNP conjugates decreased the amplitude and frequency of spike-wave-like discharges (SWDs) and alleviated the anxiety-like behavior as assessed by EEG and elevated plus-maze test, respectively (p
ISSN:0920-1211
1872-6844
1872-6844
DOI:10.1016/j.eplepsyres.2022.106939