Loading…

LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans

Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study t...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2024-10, Vol.26 (10), p.4734-4743
Main Authors: Andreoli, María F., Kruger, Ana Luz, Sokolov, Aleksandr V., Rukh, Gull, De Francesco, Pablo N., Perello, Mario, Schiöth, Helgi B.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c2800-5556bc7e9142e2229dbb25b320f683534d8f0c60a0ce7c355cab23eab538f76a3
container_end_page 4743
container_issue 10
container_start_page 4734
container_title Diabetes, obesity & metabolism
container_volume 26
creator Andreoli, María F.
Kruger, Ana Luz
Sokolov, Aleksandr V.
Rukh, Gull
De Francesco, Pablo N.
Perello, Mario
Schiöth, Helgi B.
description Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study the association between fasting LEAP2 and anthropometric and metabolic traits, feeding behaviour, LEAP2 genetic variants and blood cell DNA methylation status; and (c) to ascertain postprandial changes in LEAP2 after high protein intake and the association with feeding behaviour and food intake. Methods Anthropometric and behavioural measures, genotyping, methylation profiling, plasma glucose and LEAP2 concentrations were assessed in 327 females and males. A subgroup of 123 participants received an ad libitum high‐protein meal, and postprandial LEAP2 concentration and behavioural measures were assessed. Results LEAP2 concentration was higher in participants with OW/OB (p 
doi_str_mv 10.1111/dom.15850
format article
fullrecord <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_DiVA_org_uu_537719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3092871203</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2800-5556bc7e9142e2229dbb25b320f683534d8f0c60a0ce7c355cab23eab538f76a3</originalsourceid><addsrcrecordid>eNp1kctu1DAUhiMEoqWw4AWQJTYgkdaXOJflqBdAGlQWwNZynJOOS2JPfWxG8wx9acykdIGEN8c6_vzp2H9RvGb0lOV1Nvj5lMlW0ifFMatqUTLB66eHPS_bjvKj4gXiLaW0Em3zvDgSHasoZ91xcb--XH3lxCLRiN5YHWEgOxs3xM7bNKH9ZeOeaDeQADsdBoLg0MalPcAW3GDdDfGOxA0Ql2LIh97piWDUMeHh6gAmgEbAxbwNPoJ1xLqof0IuZJNm7fBl8WzUE8Krh3pSfL-6_Hb-qVxff_x8vlqXhreUllLKujcN5Ddw4Jx3Q99z2QtOx7oVUlRDO1JTU00NNEZIaXTPBeheinZsai1Oig-LF3ewTb3aBjvrsFdeW3Vhf6yUDzcqJSVF07Au4-8WPM99lwCjmi0amCbtwCdUgna8bRinIqNv_0FvfQr5NzLFaC2qquNNpt4vlAkeMcD4OAGj6k-gKgeqDoFm9s2DMfUzDI_k3wQzcLYAOzvB_v8mdXH9ZVH-BpT5q9E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3106344927</pqid></control><display><type>article</type><title>LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Andreoli, María F. ; Kruger, Ana Luz ; Sokolov, Aleksandr V. ; Rukh, Gull ; De Francesco, Pablo N. ; Perello, Mario ; Schiöth, Helgi B.</creator><creatorcontrib>Andreoli, María F. ; Kruger, Ana Luz ; Sokolov, Aleksandr V. ; Rukh, Gull ; De Francesco, Pablo N. ; Perello, Mario ; Schiöth, Helgi B.</creatorcontrib><description>Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study the association between fasting LEAP2 and anthropometric and metabolic traits, feeding behaviour, LEAP2 genetic variants and blood cell DNA methylation status; and (c) to ascertain postprandial changes in LEAP2 after high protein intake and the association with feeding behaviour and food intake. Methods Anthropometric and behavioural measures, genotyping, methylation profiling, plasma glucose and LEAP2 concentrations were assessed in 327 females and males. A subgroup of 123 participants received an ad libitum high‐protein meal, and postprandial LEAP2 concentration and behavioural measures were assessed. Results LEAP2 concentration was higher in participants with OW/OB (p &lt; 0.001) and in females (p &lt; 0.001), and was associated with LEAP2 single nucleotide polymorphisms rs765760 (p = 0.012) and rs803223 (p = 0.019), but not with LEAP2 methylation status. LEAP2 concentration was directly related to glycaemia (p = 0.001) and fullness (p = 0.003) in participants with normal weight, whereas it was associated with body mass index (p = 0.018), waist circumference (p = 0.014) and motor impulsivity in participants with OW/OB (p = 0.005). A negative association with reward responsiveness was observed in participants with OW/OB (p = 0.023). LEAP2 concentration was inversely associated with food intake (p = 0.034) and decreased after a high‐protein meal (p &lt; 0.001), particularly in women (p = 0.002). Conclusion Increased LEAP2 in participants with OW/OB is associated with behavioural characteristics of obesity. Our results show sexual dimorphism in LEAP2 concentration before and after food intake and highlight the role of LEAP2 in feeding regulation.</description><identifier>ISSN: 1462-8902</identifier><identifier>ISSN: 1463-1326</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.15850</identifier><identifier>PMID: 39140219</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Antimicrobial peptides ; Blood glucose ; Body mass index ; DNA methylation ; Fasting ; Feeding behavior ; feeding behaviour ; Food intake ; Genetic diversity ; Genotyping ; Impulsive behavior ; Impulsivity ; LEAP2 ; Nutritional status ; Obesity ; Proteins ; reward sensitivity ; Sexual dimorphism ; Single-nucleotide polymorphism</subject><ispartof>Diabetes, obesity &amp; metabolism, 2024-10, Vol.26 (10), p.4734-4743</ispartof><rights>2024 The Author(s). published by John Wiley &amp; Sons Ltd.</rights><rights>2024 The Author(s). Diabetes, Obesity and Metabolism published by John Wiley &amp; Sons Ltd.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2800-5556bc7e9142e2229dbb25b320f683534d8f0c60a0ce7c355cab23eab538f76a3</cites><orcidid>0000-0001-8987-6348</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39140219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-537719$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Andreoli, María F.</creatorcontrib><creatorcontrib>Kruger, Ana Luz</creatorcontrib><creatorcontrib>Sokolov, Aleksandr V.</creatorcontrib><creatorcontrib>Rukh, Gull</creatorcontrib><creatorcontrib>De Francesco, Pablo N.</creatorcontrib><creatorcontrib>Perello, Mario</creatorcontrib><creatorcontrib>Schiöth, Helgi B.</creatorcontrib><title>LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans</title><title>Diabetes, obesity &amp; metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study the association between fasting LEAP2 and anthropometric and metabolic traits, feeding behaviour, LEAP2 genetic variants and blood cell DNA methylation status; and (c) to ascertain postprandial changes in LEAP2 after high protein intake and the association with feeding behaviour and food intake. Methods Anthropometric and behavioural measures, genotyping, methylation profiling, plasma glucose and LEAP2 concentrations were assessed in 327 females and males. A subgroup of 123 participants received an ad libitum high‐protein meal, and postprandial LEAP2 concentration and behavioural measures were assessed. Results LEAP2 concentration was higher in participants with OW/OB (p &lt; 0.001) and in females (p &lt; 0.001), and was associated with LEAP2 single nucleotide polymorphisms rs765760 (p = 0.012) and rs803223 (p = 0.019), but not with LEAP2 methylation status. LEAP2 concentration was directly related to glycaemia (p = 0.001) and fullness (p = 0.003) in participants with normal weight, whereas it was associated with body mass index (p = 0.018), waist circumference (p = 0.014) and motor impulsivity in participants with OW/OB (p = 0.005). A negative association with reward responsiveness was observed in participants with OW/OB (p = 0.023). LEAP2 concentration was inversely associated with food intake (p = 0.034) and decreased after a high‐protein meal (p &lt; 0.001), particularly in women (p = 0.002). Conclusion Increased LEAP2 in participants with OW/OB is associated with behavioural characteristics of obesity. Our results show sexual dimorphism in LEAP2 concentration before and after food intake and highlight the role of LEAP2 in feeding regulation.</description><subject>Antimicrobial peptides</subject><subject>Blood glucose</subject><subject>Body mass index</subject><subject>DNA methylation</subject><subject>Fasting</subject><subject>Feeding behavior</subject><subject>feeding behaviour</subject><subject>Food intake</subject><subject>Genetic diversity</subject><subject>Genotyping</subject><subject>Impulsive behavior</subject><subject>Impulsivity</subject><subject>LEAP2</subject><subject>Nutritional status</subject><subject>Obesity</subject><subject>Proteins</subject><subject>reward sensitivity</subject><subject>Sexual dimorphism</subject><subject>Single-nucleotide polymorphism</subject><issn>1462-8902</issn><issn>1463-1326</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kctu1DAUhiMEoqWw4AWQJTYgkdaXOJflqBdAGlQWwNZynJOOS2JPfWxG8wx9acykdIGEN8c6_vzp2H9RvGb0lOV1Nvj5lMlW0ifFMatqUTLB66eHPS_bjvKj4gXiLaW0Em3zvDgSHasoZ91xcb--XH3lxCLRiN5YHWEgOxs3xM7bNKH9ZeOeaDeQADsdBoLg0MalPcAW3GDdDfGOxA0Ql2LIh97piWDUMeHh6gAmgEbAxbwNPoJ1xLqof0IuZJNm7fBl8WzUE8Krh3pSfL-6_Hb-qVxff_x8vlqXhreUllLKujcN5Ddw4Jx3Q99z2QtOx7oVUlRDO1JTU00NNEZIaXTPBeheinZsai1Oig-LF3ewTb3aBjvrsFdeW3Vhf6yUDzcqJSVF07Au4-8WPM99lwCjmi0amCbtwCdUgna8bRinIqNv_0FvfQr5NzLFaC2qquNNpt4vlAkeMcD4OAGj6k-gKgeqDoFm9s2DMfUzDI_k3wQzcLYAOzvB_v8mdXH9ZVH-BpT5q9E</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Andreoli, María F.</creator><creator>Kruger, Ana Luz</creator><creator>Sokolov, Aleksandr V.</creator><creator>Rukh, Gull</creator><creator>De Francesco, Pablo N.</creator><creator>Perello, Mario</creator><creator>Schiöth, Helgi B.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><orcidid>https://orcid.org/0000-0001-8987-6348</orcidid></search><sort><creationdate>202410</creationdate><title>LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans</title><author>Andreoli, María F. ; Kruger, Ana Luz ; Sokolov, Aleksandr V. ; Rukh, Gull ; De Francesco, Pablo N. ; Perello, Mario ; Schiöth, Helgi B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2800-5556bc7e9142e2229dbb25b320f683534d8f0c60a0ce7c355cab23eab538f76a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antimicrobial peptides</topic><topic>Blood glucose</topic><topic>Body mass index</topic><topic>DNA methylation</topic><topic>Fasting</topic><topic>Feeding behavior</topic><topic>feeding behaviour</topic><topic>Food intake</topic><topic>Genetic diversity</topic><topic>Genotyping</topic><topic>Impulsive behavior</topic><topic>Impulsivity</topic><topic>LEAP2</topic><topic>Nutritional status</topic><topic>Obesity</topic><topic>Proteins</topic><topic>reward sensitivity</topic><topic>Sexual dimorphism</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andreoli, María F.</creatorcontrib><creatorcontrib>Kruger, Ana Luz</creatorcontrib><creatorcontrib>Sokolov, Aleksandr V.</creatorcontrib><creatorcontrib>Rukh, Gull</creatorcontrib><creatorcontrib>De Francesco, Pablo N.</creatorcontrib><creatorcontrib>Perello, Mario</creatorcontrib><creatorcontrib>Schiöth, Helgi B.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Archive</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Diabetes, obesity &amp; metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andreoli, María F.</au><au>Kruger, Ana Luz</au><au>Sokolov, Aleksandr V.</au><au>Rukh, Gull</au><au>De Francesco, Pablo N.</au><au>Perello, Mario</au><au>Schiöth, Helgi B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans</atitle><jtitle>Diabetes, obesity &amp; metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2024-10</date><risdate>2024</risdate><volume>26</volume><issue>10</issue><spage>4734</spage><epage>4743</epage><pages>4734-4743</pages><issn>1462-8902</issn><issn>1463-1326</issn><eissn>1463-1326</eissn><abstract>Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study the association between fasting LEAP2 and anthropometric and metabolic traits, feeding behaviour, LEAP2 genetic variants and blood cell DNA methylation status; and (c) to ascertain postprandial changes in LEAP2 after high protein intake and the association with feeding behaviour and food intake. Methods Anthropometric and behavioural measures, genotyping, methylation profiling, plasma glucose and LEAP2 concentrations were assessed in 327 females and males. A subgroup of 123 participants received an ad libitum high‐protein meal, and postprandial LEAP2 concentration and behavioural measures were assessed. Results LEAP2 concentration was higher in participants with OW/OB (p &lt; 0.001) and in females (p &lt; 0.001), and was associated with LEAP2 single nucleotide polymorphisms rs765760 (p = 0.012) and rs803223 (p = 0.019), but not with LEAP2 methylation status. LEAP2 concentration was directly related to glycaemia (p = 0.001) and fullness (p = 0.003) in participants with normal weight, whereas it was associated with body mass index (p = 0.018), waist circumference (p = 0.014) and motor impulsivity in participants with OW/OB (p = 0.005). A negative association with reward responsiveness was observed in participants with OW/OB (p = 0.023). LEAP2 concentration was inversely associated with food intake (p = 0.034) and decreased after a high‐protein meal (p &lt; 0.001), particularly in women (p = 0.002). Conclusion Increased LEAP2 in participants with OW/OB is associated with behavioural characteristics of obesity. Our results show sexual dimorphism in LEAP2 concentration before and after food intake and highlight the role of LEAP2 in feeding regulation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>39140219</pmid><doi>10.1111/dom.15850</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8987-6348</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1462-8902
ispartof Diabetes, obesity & metabolism, 2024-10, Vol.26 (10), p.4734-4743
issn 1462-8902
1463-1326
1463-1326
language eng
recordid cdi_swepub_primary_oai_DiVA_org_uu_537719
source Wiley-Blackwell Read & Publish Collection
subjects Antimicrobial peptides
Blood glucose
Body mass index
DNA methylation
Fasting
Feeding behavior
feeding behaviour
Food intake
Genetic diversity
Genotyping
Impulsive behavior
Impulsivity
LEAP2
Nutritional status
Obesity
Proteins
reward sensitivity
Sexual dimorphism
Single-nucleotide polymorphism
title LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T17%3A19%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LEAP2%20is%20associated%20with%20impulsivity%20and%20reward%20sensitivity%20depending%20on%20the%20nutritional%20status%20and%20decreases%20with%20protein%20intake%20in%20humans&rft.jtitle=Diabetes,%20obesity%20&%20metabolism&rft.au=Andreoli,%20Mar%C3%ADa%20F.&rft.date=2024-10&rft.volume=26&rft.issue=10&rft.spage=4734&rft.epage=4743&rft.pages=4734-4743&rft.issn=1462-8902&rft.eissn=1463-1326&rft_id=info:doi/10.1111/dom.15850&rft_dat=%3Cproquest_swepu%3E3092871203%3C/proquest_swepu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2800-5556bc7e9142e2229dbb25b320f683534d8f0c60a0ce7c355cab23eab538f76a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3106344927&rft_id=info:pmid/39140219&rfr_iscdi=true