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Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri

Three new dihydroflavonols, gloverinols A–C (1–3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS da...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2024-09, Vol.87 (9), p.2263-2271
Main Authors:	Kiganda, Ivan, Wieske, Lianne H. E., Nchiozem-Ngnitedem, Vaderament-Alexe, Chalo, Duncan, Umereweneza, Daniel, Ndakala, Albert, Herrebout, Wouter, Xiong, Ruisheng, Karpiński, Tomasz M., Yenesew, Abiy, Erdelyi, Mate
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology bark Dalbergia Dalbergia - chemistry Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology isoflavans Isoflavones - chemistry Isoflavones - isolation & purification Isoflavones - pharmacology Microbial Sensitivity Tests Molecular Structure Plant Bark - chemistry Plant Roots - chemistry Staphylococcus aureus Staphylococcus aureus - drug effects
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cites	cdi_FETCH-LOGICAL-a399t-130605cd4ce09265f30c63f65e85a0119b3fc77b3d6d5dc26a29b284c2978f663
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creator	Kiganda, Ivan Wieske, Lianne H. E. Nchiozem-Ngnitedem, Vaderament-Alexe Chalo, Duncan Umereweneza, Daniel Ndakala, Albert Herrebout, Wouter Xiong, Ruisheng Karpiński, Tomasz M. Yenesew, Abiy Erdelyi, Mate
description	Three new dihydroflavonols, gloverinols A–C (1–3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (2), gloveriflavan B (6), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (10) were the most active against Staphylococcus aureus, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.
doi_str_mv	10.1021/acs.jnatprod.4c00690
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subjects	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology bark Dalbergia Dalbergia - chemistry Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology isoflavans Isoflavones - chemistry Isoflavones - isolation & purification Isoflavones - pharmacology Microbial Sensitivity Tests Molecular Structure Plant Bark - chemistry Plant Roots - chemistry Staphylococcus aureus Staphylococcus aureus - drug effects
title	Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri
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