Oxidative Stress and Changes in α- and γ-Tocopherol Levels during Coronary Artery Bypass Grafting

: We studied whether cardiopulmonary bypass (CPB) has any immediate impact on the initiation of antioxidative defenses in the body by measuring F2‐isoprostanes and α‐ and γ‐tocopherol, respectively. 8‐iso‐PGF2α levels increased significantly within 3 minutes and until the end of CPB. α‐Tocopherol le...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-12, Vol.1031 (1), p.352-356
Main Authors: ULUS, A T, AKSOYEK, A, OZKAN, M, KATIRCIOGLU, S F, VESSBY, B, BASU, S
Format: Article
Language:English
Subjects:
Adult
Aged
alpha-Tocopherol - blood
antioxidants
Antioxidants - analysis
cardiopulmonary bypass
Coronary Artery Bypass
Female
gamma-Tocopherol - blood
Humans
ischemia-reperfusion
isoprostanes
Male
Middle Aged
Oxidative Stress
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Summary:: We studied whether cardiopulmonary bypass (CPB) has any immediate impact on the initiation of antioxidative defenses in the body by measuring F2‐isoprostanes and α‐ and γ‐tocopherol, respectively. 8‐iso‐PGF2α levels increased significantly within 3 minutes and until the end of CPB. α‐Tocopherol levels increased gradually at 20 min during CPB and continued until 6 hours after CPB. γ‐Tocopherol levels followed a similar fashion at the end of CPB. 8‐iso‐PGF2α and tocopherol levels kept at basal level 12 and 24 hours post CPB. These findings suggest that an increased free radical‐induced oxidative stress together with a gradual appearance of antioxidative defense system during and after CPB.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1331.043