Sex steroid levels temporarily increase in response to acute psychosocial stress in healthy men and women

• Published in: International journal of psychophysiology 2012-06, Vol.84 (3), p.246-253
• Main Authors: Lennartsson, Anna-Karin, Kushnir, Mark M., Bergquist, Jonas, Billig, Håkan, Jonsdottir, Ingibjörg H.
• Format: Article
• Language: English
• Subjects: acute psychological stress; Acute stress; Adrenocorticotropic hormone; Adult; Age; Androgens; Androstenedione; axis; Behavioral psychophysiology; Biological and medical sciences; Biomarkers - blood; Blood pressure; Blood Pressure - physiology; Clinical Medicine; Cohort Studies; cortisol; dehydroepiandrosterone; Estradiol; estrogen; Female; Fundamental and applied biological sciences. Psychology; Globulins; Gonadal Steroid Hormones - blood; Health Status; Heart rate; Heart Rate - physiology; hormone; Humans; Hydrocortisone; Hypothalamic-pituitary-adrenal axis; Hypothalamo-Hypophyseal System - metabolism; Hypothalamus; Immunoassays; Klinisk medicin; Male; mass-spectrometry assay; Men and women; Middle Aged; Pituitary-Adrenal System - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; serum; Sex; Sex hormone-binding globulin; sex hormone-binding gloublin; Sex hormones; Sex steroids; Social interactions; Steroid hormones; Stress; Stress, Psychological - blood; Stress, Psychological - psychology; Sympathetic nervous system; Testosterone; Time Factors; Trier Social Stress Test
• ISSN: 0167-8760; 1872-7697; 1872-7697
• DOI: 10.1016/j.ijpsycho.2012.03.001

It is well known that acute psychosocial stress activates the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system (SNS). However, the effect of acute psychosocial stress on the hypothalamic–pituitary–gonadal (HPG) axis and levels of sex steroids are less known. The aim of this study was to investigate the effect of acute psychosocial stress on serum concentrations of sex steroids in healthy men and women. Twenty men and 19 women (age 30–50years) underwent Trier Social Stress Test (TSST), a tool for investigating psychobiological stress responses in a laboratory setting. Blood samples were collected before, directly after the stress test, and after 30min of recovery. Concentrations of androgens were measured with high specificity LC-MS/MS method; concentrations of cortisol, estradiol and sex hormone-binding globulin were determined using immunoassays. In both men and women we observed significantly elevated levels of testosterone, estradiol, androstenedione and sex hormone binding globulin along with significantly increased adrenocorticotropic hormone (ACTH), serum cortisol, heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) as a response to the stressor. Thus, even though the HPG axis and the production of sex steroids may be inhibited during prolonged periods of stress, the sex steroid levels may increase in the initial phase of acute psychosocial stress. ► Sex steroid levels increased in response to acute psychosocial stress in both sexes. ► Magnitude of increase of sex steroids varied considerably among the participants. ► Sex steroid responses are, to some extent, related to ACTH, cortisol and HR responses. ► The increase in sex steroids is transient, as reduced levels are seen shortly after.