Nebulised racemic adrenaline in the treatment of acute bronchiolitis in infants and toddlers

The effect of inhaled nebulised racemic adrenaline upon symptoms of acute bronchiolitis was investigated in 29 infants and toddlers aged 2-17.5 months by transcutaneous oxygen tension (TcPO2), oxygen saturation, transcutaneous carbon dioxide tension (TcPCO2), and clinical evaluation in a double blin...

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Bibliographic Details
Published in:Archives of disease in childhood 1993-12, Vol.69 (6), p.650-654
Main Authors: Kristjánsson, S, Lødrup Carlsen, K C, Wennergren, G, Strannegård, I L, Carlsen, K H
Format: Article
Language:English
Subjects:
Acute Disease
Administration
administration & dosage
Administration, Inhalation
Biological and medical sciences
blood
Blood Gas Monitoring
Blood Gas Monitoring, Transcutaneous
Blood Pressure
Blood Pressure - drug effects
Bronchiolitis
Bronchiolitis - blood
Bronchiolitis - drug therapy
Bronchopneumonia
Carbon dioxide
drug effects
drug therapy
Epinephrine
Epinephrine - administration & dosage
Female
Heart rate
Humans
Infant
Infants
Inhalation
Male
Medical sciences
Oxygen tension
Oxygenation
Pediatrics
Pediatrik
Placebos
Pneumology
Racepinephrine
Respiratory system : syndromes and miscellaneous diseases
Time Factors
Transcutaneous
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Summary:The effect of inhaled nebulised racemic adrenaline upon symptoms of acute bronchiolitis was investigated in 29 infants and toddlers aged 2-17.5 months by transcutaneous oxygen tension (TcPO2), oxygen saturation, transcutaneous carbon dioxide tension (TcPCO2), and clinical evaluation in a double blind placebo controlled study. Clinical score and TcPO2 improved significantly at 30, 45, and 60 minutes after inhalation of racemic adrenaline, with an increase in TcPO2 > or = 0.5 kPa in 72% of the children < 1 year of age. No significant improvement was observed after inhalation of placebo. No significant changes in heart rate or TcPCO2 were observed from before to after inhalation, but a small increase in mean systolic blood pressure was observed immediately and 45 minutes after racemic adrenaline inhalation. This study demonstrates that treatment with nebulised racemic adrenaline improved oxygenation and clinical signs in hospitalised children aged less than 18 months with bronchiolitis.
ISSN:0003-9888
1468-2044
1468-2044
DOI:10.1136/adc.69.6.650