Neural control of blood pressure in women: differences according to age

Purpose The blood pressure “error signal” represents the difference between an individual’s mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the “T50”). In this study we evaluated whether T50...

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Bibliographic Details
Published in:Clinical autonomic research 2017-06, Vol.27 (3), p.157-165
Main Authors: Peinado, Ana B., Harvey, Ronee E., Hart, Emma C., Charkoudian, Nisha, Curry, Timothy B., Nicholson, Wayne T., Wallin, B. Gunnar, Joyner, Michael J., Barnes, Jill N.
Format: Article
Language:English
Subjects:
17-BETA-ESTRADIOL
Adult
Aged
Aging
Aging - physiology
ARTERIAL-PRESSURE
Autonomic Agents - pharmacology
Autonomic nervous system
AUTONOMIC SUPPORT
BALANCE
Baroreceptors
Baroreflex - drug effects
Baroreflex - physiology
Baroreflex function
BAROREFLEX SENSITIVITY
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiology
Data processing
Diabetes
Endocrinology
ESTROGEN
Female
Ganglionic Blockers - pharmacology
Gastroenterology
Heart diseases
Hemodynamics - drug effects
Hemodynamics - physiology
HUMANS
LONG-TERM CONTROL
Medicine
Medicine & Public Health
Menopause
Menopause - physiology
Middle Aged
MODULATION
Muscle, Skeletal - innervation
Muscle, Skeletal - physiology
Neurology
Neurosciences
Neurovetenskaper
Ophthalmology
Post-menopause
Postmenopause - physiology
Premenopause - physiology
Reflexes
Research Article
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
SYMPATHETIC-NERVE ACTIVITY
Trimethaphan - pharmacology
Vasodilator Agents - pharmacology
Young Adult
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Summary:Purpose The blood pressure “error signal” represents the difference between an individual’s mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the “T50”). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause. Methods We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25 ± 1 years) and 12 postmenopausal women (61 ± 2 years) before and during complete autonomic blockade with trimethaphan camsylate. Results At baseline, young women had a negative error signal (−8 ± 1 versus 2 ± 1 mmHg, p  
ISSN:0959-9851
1619-1560
DOI:10.1007/s10286-017-0403-0