A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs?

Based on studies delivering ghrelin or ghrelin receptor agonists, we have learned a great deal about the importance of the brain ghrelin signalling system for a wide range of physiological processes that include feeding behaviours, growth hormone secretion and glucose homeostasis. Because these proc...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2021-11, Vol.33 (11), p.e13025-n/a
Main Authors: Peris‐Sampedro, Fiona, Le May, Marie V., Stoltenborg, Iris, Schéle, Erik, Dickson, Suzanne L.
Format: Article
Language:English
Subjects:
Animal models
appetite
arcuate nucleus
body growth
bone density
decrease food-intake
deficient mice
des-acyl ghrelin
Endocrinology & Metabolism
Endocrinology and Diabetes
Endokrinologi och diabetes
food intake
Ghrelin
ghrelin knockout
GHSR
GHSR knockout
Ghsr-IRES-cre
GOAT
GOAT knockout
growth hormone
Growth hormones
high-fat diet
Homeostasis
hormone secretagogue receptor
hunger
insulin sensitivity
knockout
Neurosciences & Neurology
o-acyltransferase goat
Phenotypes
pituitary-adrenal axis
transgenic mice
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Summary:Based on studies delivering ghrelin or ghrelin receptor agonists, we have learned a great deal about the importance of the brain ghrelin signalling system for a wide range of physiological processes that include feeding behaviours, growth hormone secretion and glucose homeostasis. Because these processes can be considered as essential to life, the question arises as to why mouse models of depleted ghrelin signalling are not all skinny dwarfs with a host of behavioural and metabolic problems. Here, we provide a systematic detailed review of the phenotype of mice with deficient ghrelin signalling to help better understand the relevance and importance of the brain ghrelin signalling system, with a particular emphasis on those questions that remain unanswered. Hunting for the skinny dwarfs in ghrelin research.
ISSN:0953-8194
1365-2826
DOI:10.1111/jne.13025