Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using HRpQCT

• Published in: Osteoporosis international 2022-01, Vol.33 (1), p.205-216
• Main Authors: Deminger, A., Klingberg, E., Lorentzon, M., Hedberg, M., Carlsten, H., Jacobsson, L.T.H., Forsblad-d’Elia, H.
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Ankylosing spondylitis; Arthritis; Bisphosphonates; Bone Density; Bone loss; Bone mineral density; Computed tomography; Cortical Bone; DXA; Endocrinology; high-resolution peripheral quantitative computed tomography; Humans; Male; Medicine; Medicine & Public Health; Original; Original Article; Orthopedics; Osteoporosis; other diseases related to bone (ankylosing spondylitis); Patients; Prospective Studies; radiology; Radius; Radius - diagnostic imaging; Regression analysis; Reumatologi och inflammation; Rheumatology; Rheumatology and Autoimmunity; Skeleton; Spondylitis, Ankylosing - diagnostic imaging; Spondylitis, Ankylosing - drug therapy; Tibia; Tibia - diagnostic imaging; Tomography; Tumor necrosis factor
• ISSN: 0937-941X; 1433-2965; 1433-2965
• DOI: 10.1007/s00198-021-06049-4

Summary Patients with ankylosing spondylitis (AS) have impaired volumetric bone mineral density (vBMD) assessed with high-resolution peripheral computed tomography (HRpQCT). This first longitudinal HRpQCT study in AS shows that cortical and trabecular vBMD decreased at tibia and that signs of inflammation were associated with cortical bone loss at tibia and radius. Introduction Patients with ankylosing spondylitis (AS) have reduced volumetric bone mineral density (vBMD) in the peripheral skeleton assessed with high-resolution peripheral quantitative computed tomography (HRpQCT). The aims were to investigate longitudinal changes in vBMD, cortical area, and microarchitecture and to assess factors associated with changes in vBMD and cortical area in men with AS. Methods HRpQCT of radius and tibia was performed in 54 men with AS at baseline and after 5 years. Univariate and multivariable linear regression analyses were used. Results At tibia, there were significant decreases exceeding least significant changes (LSC) in cortical and trabecular vBMD, mean (SD) percent change −1.0 (1.9) and −2.7 (5.0) respectively (p