Slowly‐adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation

Slowly‐adapting type II (SA‐II, Ruffini) mechanoreceptive afferents respond well to pressure and stretch, and are regularly encountered in human microneurography studies. Despite an understanding of SA‐II response properties, their role in touch perception remains unclear. Specific roles of differen...

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Bibliographic Details
Published in:The Journal of physiology 2022-06, Vol.600 (12), p.2939-2952
Main Authors: Watkins, Roger Holmes, Durao de Carvalho Amante, Mario, Backlund Wasling, Helena, Wessberg, Johan, Ackerley, Rochelle
Format: Article
Language:English
Subjects:
Cognitive science
Computational neuroscience
cutaneous
Feedback
Fysiologi
glabrous
hairy skin
human hand
mechanoreceptive units
mechanoreceptor
Mechanoreceptors
Microneurography
neural coding mechanisms
Neuroscience
Neurosciences
Neurosciences & Neurology
Neurovetenskaper
Perceptions
peripheral projections
Physiology
Pressure
Receptive field
receptive-field characteristics
responses
Ruffini
SA-II
Sensation
Sensory neurons
Skin
tactile
tactile afferents
Tactile perception
Tactile stimuli
touch
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Summary:Slowly‐adapting type II (SA‐II, Ruffini) mechanoreceptive afferents respond well to pressure and stretch, and are regularly encountered in human microneurography studies. Despite an understanding of SA‐II response properties, their role in touch perception remains unclear. Specific roles of different myelinated Aβ mechanoreceptive afferents in tactile perception have been revealed using single unit intraneural microstimulation (INMS), via microneurography, recording from and then electrically stimulating individual afferents. This method directly links single afferent artificial activation to perception, where INMS produces specific ‘quantal’ touch percepts associated with different mechanoreceptive afferent types. However, SA‐II afferent stimulation has been ambiguous, producing inconsistent, vague sensations, or no clear percept. We physiologically characterized hundreds of individual Aβ mechanoreceptive afferents in the glabrous hand skin and examined the subsequent percepts evoked by trains of low amplitude INMS current pulses (
ISSN:0022-3751
1469-7793
DOI:10.1113/JP282873