A risk-scoring model for the differential diagnosis of lentigo maligna and other atypical pigmented facial lesions of the face: The facial iDScore

• Published in: Journal of the European Academy of Dermatology and Venereology 2023-11, Vol.37 (11), p.2301-2310
• Main Authors: Tognetti, Linda, Cartocci, Alessandra, Żychowska, Magdalena, Savarese, Imma, Cinotti, Elisa, Pizzichetta, Maria Antonietta, Moscarella, Elvira, Longo, Caterina, Farnetani, Francesca, Guida, Stefania, Paoli, John, Lallas, Aimilios, Tiodorovic, Danica, Stanganelli, Ignazio, Magi, Serena, Dika, Emi, Zalaudek, Iris, Suppa, Mariano, Argenziano, Giuseppe, Pellacani, Giovanni, Perrot, Jean Luc, Miracapillo, Chiara, Rubegni, Giovanni, Cevenini, Gabriele, Rubegni, Pietro
• Format: Article
• Language: English
• Subjects: accuracy; actinic keratosis; Dermatologi och venereologi; Dermatology; Dermatology and Venereal Diseases; dermatoscopy; dermoscopic differentiation; macules; melanoma; sun-damaged skin
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/jdv.19360

Due to progressive ageing of the population, the incidence of facial lentigo maligna (LM) of the face is increasing. Many benign simulators of LM and LMM, known as atypical pigmented facial lesions (aPFLs-pigmented actinic keratosis, solar lentigo, seborrheic keratosis, seborrheic-lichenoid keratosis, atypical nevus) may be found on photodamaged skin. This generates many diagnostic issues and increases the number of biopsies, with a subsequent impact on aesthetic outcome and health insurance costs. Our aim was to develop a risk-scoring classifier-based algorithm to estimate the probability of an aPFL being malignant. A second aim was to compare its diagnostic accuracy with that of dermoscopists so as to define the advantages of using the model in patient management. A total of 154 dermatologists analysed 1111 aPFLs and their management in a teledermatology setting: They performed pattern analysis, gave an intuitive clinical diagnosis and proposed lesion management options (follow-up/reflectance confocal microscopy/biopsy). Each case was composed of a dermoscopic and/or clinical picture plus metadata (histology, age, sex, location, diameter). The risk-scoring classifier was developed and tested on this dataset and then validated on 86 additional aPFLs. The facial Integrated Dermoscopic Score (iDScore) model consisted of seven dermoscopic variables and three objective parameters (diameter ≥ 8 mm, age ≥ 70 years, male sex); the score ranged from 0 to 16. In the testing set, the facial iDScore-aided diagnosis was more accurate (AUC = 0.79 [IC 95% 0.757-0.843]) than the intuitive diagnosis proposed by dermatologists (average of 43.5%). In the management study, the score model reduced the number of benign lesions sent for biopsies by 41.5% and increased the number of LM/LMM cases sent for reflectance confocal microscopy or biopsy instead of follow-up by 66%. The facial iDScore can be proposed as a feasible tool for managing patients with aPFLs.