Parity and Risk of Thyroid Cancer: A Nested Case-Control Study of a Nationwide Swedish Cohort

The association between parity and risk of thyroid cancer was examined in a case-control study nested within a cohort of Swedish women born 1925-60. A total of 1,409 cases of thyroid cancer were compared with 7,019 age-matched controls. Odds ratios (OR) and 95 percent confidence intervals (CI) were...

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Bibliographic Details
Published in:Cancer causes & control 1995-01, Vol.6 (1), p.37-44
Main Authors: Galanti, Maria Rosaria, Lambe, Mats, Ekbom, Anders, Sparén, Pär, Pettersson, Bo
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - epidemiology
Adenocarcinoma, Papillary - epidemiology
Adolescent
Adult
Cancer
Case control studies
Cohort Studies
Conception
Confidence interval
Estrogens
Female
Gender equality
Histology
Humans
Incidence
Likelihood Functions
Logistic Models
Maternal Age
Medicin och hälsovetenskap
Middle Aged
Odds Ratio
Papillae
Parity
Pregnancy
Registries
Research Papers
Risk Factors
Sweden - epidemiology
Thyroid cancer
Thyroid Neoplasms - epidemiology
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Summary:The association between parity and risk of thyroid cancer was examined in a case-control study nested within a cohort of Swedish women born 1925-60. A total of 1,409 cases of thyroid cancer were compared with 7,019 age-matched controls. Odds ratios (OR) and 95 percent confidence intervals (CI) were calculated as estimates of relative risk. A weak association was found between parity and risk of thyroid cancer (OR for ever-parous women cf nulliparous was 1.1, CI = 1.0-1.3). For the subset of papillary cancers, there was a significantly increased risk (OR for ever-parous cf nulliparous = 1.3, CI = 1.0-1.6), and among women diagnosed at the age of 50 or older, there was a positive linear trend with increasing number of livebirths. Women during the first year after a livebirth had an increased risk of thyroid cancer compared with women who delivered 10 or more years before; this association was most prominent among uniparous women (OR = 2.5, CI = 1.1-5.9). An increased risk was also apparent for age over 20 years at livebirth (among uniparous women) and age over 25 years at last livebirth (among multiparous women). A negligible effect of parity on thyroid cancer risk was seen, but each livebirth may have a short-term and age-dependent promoting effect.
ISSN:0957-5243
1573-7225
DOI:10.1007/BF00051679