Impact of breast surgery on survival in women presenting with metastatic breast cancer

Background: Advanced breast cancer is common in less affluent parts of Asia. The impact of breast surgery on survival of women presenting with metastatic breast cancer in this setting was investigated. Methods: Women presenting with metastatic breast cancer at the initial diagnosis at the University...

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Bibliographic Details
Published in:British journal of surgery 2011-11, Vol.98 (11), p.1566-1572
Main Authors: Pathy, N. Bhoo, Verkooijen, H. M., Taib, N. A., Hartman, M., Yip, C. H.
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents, Hormonal - therapeutic use
Biological and medical sciences
Breast Neoplasms - ethnology
Breast Neoplasms - mortality
Breast Neoplasms - surgery
Combined Modality Therapy - methods
Female
General aspects
Gynecology. Andrology. Obstetrics
Humans
Malaysia - epidemiology
Mammary gland diseases
Mastectomy - mortality
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Propensity Score
Survival Analysis
Tumors
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Summary:Background: Advanced breast cancer is common in less affluent parts of Asia. The impact of breast surgery on survival of women presenting with metastatic breast cancer in this setting was investigated. Methods: Women presenting with metastatic breast cancer at the initial diagnosis at the University Malaya Medical Centre (Malaysia) between 1993 and 2008 were included in the study. Mortality of patients who had primary breast surgery was compared with that of those without surgery, and adjusted for possible confounders by means of a propensity score. Results: Of 3689 patients, 375 (10·2 per cent) presented with metastatic disease. One hundred and thirty‐nine patients (37·1 per cent) underwent surgery. A total of 330 deaths occurred during 6814 person‐months of follow‐up. The 2‐year survival rate was 21·2 (95 per cent confidence interval (c.i.) 15·9 to 26·5) per cent in women who did not have surgery and 46·3 (37·7 to 54·9) per cent in those who had breast surgery. Breast surgery was associated with a 28 per cent lower risk of death (hazard ratio 0·72, 95 per cent c.i. 0·56 to 0·94), after adjustment for patient and tumour characteristics, metastatic profile and treatment. Conclusion: Surgical resection of the primary breast tumour was independently associated with a survival advantage in patients presenting with metastatic breast cancer. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Surgery prolonged survival
ISSN:0007-1323
1365-2168
1365-2168
DOI:10.1002/bjs.7650