Association of diet with serum insulin-like growth factor I in middle-aged and elderly men

• Published in: The American journal of clinical nutrition 2005-05, Vol.81 (5), p.1163-1167
• Main Authors: Larsson, S.C, Wolk, K, Brismar, K, Wolk, A
• Format: Article
• Language: English
• Subjects: Adult; Aged; alcohols; Anthropometry; Biological and medical sciences; blood serum; Body Mass Index; Diet; Diet Surveys; dietary minerals; dietary nutrient sources; dietary protein; elderly; elderly nutrition; energy intake; Feeding. Feeding behavior; fish; Fundamental and applied biological sciences. Psychology; health status; Humans; insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Male; Medicin och hälsovetenskap; Men; Middle age; Middle Aged; middle-aged adults; Minerals; nutrient intake; nutrition assessment; nutritional status; Older people; Proteins; red meat; seafoods; Smoking; Sweden; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vitamins; zinc
• ISSN: 0002-9165; 1938-3207; 1938-3207
• DOI: 10.1093/ajcn/81.5.1163

Background: Insulin-like growth factor I (IGF-I) has been implicated in several chronic diseases, including cancer, heart disease, and osteoporosis. Objective: Our aim was to assess whether intakes of total energy, alcohol, vitamins, minerals, and foods rich in protein and minerals (including red meat, fish and seafood, poultry, and milk) are associated with serum IGF-I concentrations in middle-aged and elderly men. Design: We measured serum IGF-I concentrations in 226 free-living healthy men aged 42-76 y. The average of fourteen 24-h dietary telephone interviews performed over 1 y was used to estimate long-term dietary intake. Results: We observed statistically significant positive associations between intakes of protein (P for trend = 0.001) and zinc (P for trend = 0.002) and serum IGF-I concentrations after adjusting for age. The difference in mean IGF-I concentrations for the highest compared with the lowest quintile of intake was approximately equal to 17% (162 microgram/L compared with 139 microgram/L) for protein and approximately equal to 16% (166 microgram/L compared with 143 microgram/L) for zinc. Consumption of red meat (P for trend = 0.05) and fish and seafood (P for trend = 0.07) was modestly positively associated with IGF-I concentrations. Other dietary factors were not associated with IGF-I concentrations. Conclusion: In this population of healthy well-nourished men, greater dietary intakes of protein, zinc, red meat, and fish and seafood were associated with higher IGF-I concentrations.