Sesquiterpenes from the saprotrophic fungus Granulobasidium vellereum (Ellis & Cragin) Jülich

Ten previously undescribed sesquiterpenes comprising either the protoilludane or the rare cerapicane carbon skeletons were obtained from the saprotrophic wood decomposing fungus Granulobasidium vellereum. [Display omitted] •The diversity of sesquiterpenes produced by Granulobasidium vellereum was st...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2014-06, Vol.102, p.197-204
Main Authors: Nord, Christina L., Menkis, Audrius, Lendel, Christofer, Vasaitis, Rimvydas, Broberg, Anders
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Cerapicane
Fungi - chemistry
Fungi - drug effects
Granulobasidium vellereum
Growth promotor
Microbiology
Mikrobiologi
Molecular Conformation
Organic Chemistry
Organisk kemi
Protoilludane
Sesquiterpenes
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Species Specificity
Stereoisomerism
Structural elucidation
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Summary:Ten previously undescribed sesquiterpenes comprising either the protoilludane or the rare cerapicane carbon skeletons were obtained from the saprotrophic wood decomposing fungus Granulobasidium vellereum. [Display omitted] •The diversity of sesquiterpenes produced by Granulobasidium vellereum was studied.•Ten previously undescribed compounds were found.•The compounds had either the protoilludane or the cerapicane carbon skeletons.•Granulone A showed a growth promoting effect on lettuce seedlings. Twelve sesquiterpenes comprising either the protoilludane or the rare cerapicane carbon skeletons were obtained from the saprotrophic wood decomposing fungus Granulobasidium vellereum; 2a-hydroxycoprinolone (1), 3-hydroxycoprinolone (2), coprinolone diol B (3), granulodiene A (4), granulodiene B (5), granulone A (6), 8-deoxy-4a-hydroxytsugicoline B (7), granulone B (8), demethylgranulone (9), cerapicolene (10), as well as the known compounds radudiol and Δ6-coprinolone. The structures were determined using spectroscopic methods and biosynthetic considerations. Granulone A had growth stimulating effect on the total elongation of lettuce seedlings. None of the isolated compounds showed any antifungal effect.
ISSN:0031-9422
1873-3700
1873-3700
DOI:10.1016/j.phytochem.2014.03.012