Plasma Levels of Cytokines in Primary Septic Shock in Humans: Correlation with Disease Severity

Thirteen patients (median age, 20 years) with life-threatening primary septic shock (10 meningococcal, 3 pneumococcal infections) were studied prospectively. All had a short history of sepsis (⩽ 24 h) and no severe underlying disease. Two (15%) died. The logarithm of the initial plasma levels of tum...

Full description

Saved in:
Bibliographic Details
Published in:JOURNAL OF INFECTIOUS DISEASES 1995-07, Vol.172 (1), p.296-301
Main Authors: Gårdlund, Bengt, Sjölin, Jan, Nilsson, Acke, Roll, Martin, Wickerts, Carl-Johan, Wretlind, Bengt
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Blood
Blood plasma
Concise Communications
Cytokines
Cytokines - blood
Endotoxins
Female
Hospital admissions
Humans
Insulin Receptor Substrate Proteins
Interleukin-1 - blood
Interleukin-6 - blood
Male
Medicin och hälsovetenskap
Meningococcal Infections - blood
Meningococcal Infections - immunology
Meningococcal Infections - physiopathology
Middle Aged
Phosphoproteins - blood
Plasmapheresis
Plasminogen Activator Inhibitor 1 - blood
Pneumococcal Infections - blood
Pneumococcal Infections - immunology
Pneumococcal Infections - physiopathology
Predictive Value of Tests
Prognosis
Prospective Studies
Receptors
Sepsis
Septic shock
Shock, Septic - blood
Shock, Septic - immunology
Shock, Septic - physiopathology
Time Factors
Tumor Necrosis Factor-alpha - analysis
Tumor necrosis factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thirteen patients (median age, 20 years) with life-threatening primary septic shock (10 meningococcal, 3 pneumococcal infections) were studied prospectively. All had a short history of sepsis (⩽ 24 h) and no severe underlying disease. Two (15%) died. The logarithm of the initial plasma levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-1 receptor antagonist (ra), and plasminogen activator inhibitor (PAI)-1 correlated significantly with APACHE II scores (r2 = .67, .57, .68, .81, and .68, respectively). The plasma levels of endotoxin, TNF-α, IL-1β, and PAI-1 decreased toward normal levels within the first 24 h of treatment, but IL-6 and IL-1ra levels remained high until clinical recovery. On admission, the molar excess of IL-1ra to IL-1β was >2000-fold in 11 of the 13 patients. Acute plasmapheresis in 11 of the 13 patients significantly increased the plasma clearance of TNF-α (P = .02).
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.1.296