Risk of estrogen receptor–specific breast cancer by family history of estrogen receptor subtypes and other cancers

• Published in: JNCI : Journal of the National Cancer Institute 2023-09, Vol.115 (9), p.1020-1028
• Main Authors: Wang, Qiao-Li, Zhang, Yuqi, Zeng, Erwei, Grassmann, Felix, He, Wei, Czene, Kamila
• Format: Article
• Language: English
• Subjects: Breast cancer; Confidence intervals; Estrogen receptors; Estrogens; Family medical history; Females; Genetics; Leukemia; Medicin och hälsovetenskap; Receptors; Risk; Statistical analysis; Uterine cancer
• ISSN: 0027-8874; 1460-2105; 1460-2105
• DOI: 10.1093/jnci/djad104

Abstract Background The extent to which the risk of estrogen receptor (ER)–specific breast cancer is associated with ER status of breast cancer and other cancers among first-degree relatives is unclear. Methods This population-based cohort included 464 707 cancer-free women in Stockholm, Sweden, during 1978-2019. For ER-negative and ER-positive breast cancers, we estimated hazard ratios (HRs) associated with ER status of female first-degree relatives with breast cancer and of other cancers in all first-degree relatives. Associations between ER-negative and ER-positive status by family cancer history were estimated using logistic regression in a case-only design. Results Women with familial ER-positive breast cancer had 1.87 times (95% confidence interval [CI] = 1.77 to 1.97) higher risk of ER-positive subtype, whereas the corresponding hazard ratio for ER-negative was 2.54 (95% CI = 2.08 to 3.10) when having familial ER-negative breast cancer. The risk increased with an increasing number of female first-degree relatives having concordant subtypes and younger age at diagnosis (Ptrend