Compromised periodontal status could increase mortality for patients with COVID-19

In their active surveillance study of patients with COVID-19 in south India, Ramanan Laxminarayan and colleagues1 reported an increased risk of death in patients who had a history of diabetes (adjusted hazard ratio 2·28, 95% CI 1·79–2·91), hypertension (2·08, 1·62–2·66), other circulatory disorders...

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Published in:The Lancet infectious diseases 2022-03, Vol.22 (3), p.314-314
Main Authors: Gupta, Shipra, Saarikko, Miina, Pfützner, Andreas, Räisänen, Ismo T, Sorsa, Timo
Format: Article
Language:English
Subjects:
Adult
Bacterial Infections - complications
Bronchus
Cardiovascular disease
Coronaviruses
Correspondence
COVID-19
COVID-19 - mortality
Diabetes
Diabetes mellitus
Female
Health care
Health promotion
Humans
Hypertension
Infectious diseases
Kidney diseases
Male
Mechanical ventilation
Medical education
Medical research
Medicin och hälsovetenskap
Mortality
Oral Health
Pandemics
Patients
Periodontal Diseases - complications
Periodontal Diseases - physiopathology
Periodontitis
Pneumonia
Public health
Respiratory diseases
Risk reduction
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Transcriptomes
Ventilators
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Summary:In their active surveillance study of patients with COVID-19 in south India, Ramanan Laxminarayan and colleagues1 reported an increased risk of death in patients who had a history of diabetes (adjusted hazard ratio 2·28, 95% CI 1·79–2·91), hypertension (2·08, 1·62–2·66), other circulatory disorders (3·89, 2·66–5·71), cancer (8·04, 3·47–18·65), or respiratory disorders (4·57, 2·43–8·61). Pairwise Z-testing (Bonferroni-corrected) revealed that significantly more people with periodontitis than those without died due to COVID-19 (appendix). [...]we suggest that periodontitis is not only associated with COVID-19-related outcomes2,3 but might also increase mortality in patients with COVID-19. Elevated concentrations of oral commensal bacteria have been noted from the meta-transcriptome sequencing of bronchoalveolar lavage fluid from severely ill patients with COVID-19.4 Hence, during this pandemic, preventive public health interventions and any diagnostic or treatment modalities that can help to reduce oral bioload, thereby decreasing the risk of ventilation-induced complications, are needed.5 Maintenance of oral health should assume a greater importance.
ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(22)00065-2