Infections in patients with multiple sclerosis: A national cohort study in Sweden

•Large population-based study on incident infections in MS patients.•Increased risk of incident serious/non-serious infections in MS patients.•Highest risk for urinary tract/kidney infections.•Increased risk included risk especially for respiratory/throat infections and pneumonia/influenza. Multiple...

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Bibliographic Details
Published in:Multiple sclerosis and related disorders 2020-10, Vol.45, p.102420-102420, Article 102420
Main Authors: Castelo-Branco, Anna, Chiesa, Flaminia, Conte, Simona, Bengtsson, Camilla, Lee, Sally, Minton, Neil, Niemcryk, Steve, Lindholm, Anders, Rosenlund, Mats, Piehl, Fredrik, Montgomery, Scott
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cohort Studies
Cohort study
Comorbidities
Health registers
Humans
Incidence
Infections
Medicin och hälsovetenskap
Multiple sclerosis
Multiple Sclerosis - epidemiology
Risk Assessment
Risk Factors
Sweden - epidemiology
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Summary:•Large population-based study on incident infections in MS patients.•Increased risk of incident serious/non-serious infections in MS patients.•Highest risk for urinary tract/kidney infections.•Increased risk included risk especially for respiratory/throat infections and pneumonia/influenza. Multiple sclerosis (MS) patients have an increased risk of infections, but few population-based studies have reported infections occurring in MS in the years immediately after diagnosis. To explore incident infections in MS, stratified by age and sex. In a Swedish population-based cohort study 6602 incident MS patients (aged ≥18 years), matched at diagnosis with 61,828 matched MS-free individuals were identified between 1st January 2008 and 31st December 2016, using national registers. Incidence rates (IR) and incidence rate ratios (IRR) with 95% CI were calculated for each outcome. The IRRs were 2.54 (95% CI 2.28–2.83) for first serious infection and 1.61 (1.52–1.71) for first non-serious infection. Compared with MS-free individuals, MS patients had higher IRs for skin, respiratory/throat infections, pneumonia/influenza, bacterial, viral, and fungal infections, with the highest IRR observed for urinary tract/kidney infections (2.44; 2.24–2.66). The cumulative incidence for most of these infections was higher among MS patients than MS-free individuals, both 0 to
ISSN:2211-0348
2211-0356
2211-0356
DOI:10.1016/j.msard.2020.102420