Impact of CPAP treatment on leptin and adiponectin in adults with coronary artery disease and nonsleepy obstructive sleep apnoea in the RICCADSA trial

Increased leptin and decreased adiponectin levels are reported in coronary artery disease (CAD) as well as in obstructive sleep apnoea (OSA). Less is known regarding the impact of continuous positive airway pressure (CPAP) on these biomarkers. We aimed to determine variables associated with leptin a...

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Bibliographic Details
Published in:Sleep medicine 2020-03, Vol.67, p.7-14
Main Authors: Balcan, Baran, Thunström, Erik, Yucel-Lindberg, Tülay, Lindberg, Kristin, Ay, Pinar, Peker, Yüksel
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Aged
association
Biomarkers - metabolism
c-reactive protein
Cohort Studies
Continuous Positive Airway Pressure
Coronary Artery Disease - complications
events
Female
ghrelin
Humans
insulin-resistance
Leptin
Leptin - blood
Male
Neurosciences
Neurosciences & Neurology
Neurovetenskaper
obesity
plasma
Positive airway pressure
rationale
risk-factors
Sleep Apnea, Obstructive - complications
Sleep apnoea
Sweden
Weight gain
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Summary:Increased leptin and decreased adiponectin levels are reported in coronary artery disease (CAD) as well as in obstructive sleep apnoea (OSA). Less is known regarding the impact of continuous positive airway pressure (CPAP) on these biomarkers. We aimed to determine variables associated with leptin and adiponectin in adults with CAD and nonsleepy OSA, and evaluate the effect of CPAP adjusted for confounding factors. This was one of the secondary outcomes of the RICCADSA trial, conducted in Sweden between 2005 and 2013. From 244 revascularized CAD and OSA patients (apnoea–hypopnoea index >15/h) without excessive daytime sleepiness (Epworth Sleepiness Scale score
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2019.10.016