High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B‐symptoms

Summary Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to...

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Published in:British journal of haematology 2019-01, Vol.184 (2), p.192-201
Main Authors: Gholiha, Alex R., Hollander, Peter, Hedstrom, Gustaf, Sundstrom, Christer, Molin, Daniel, Smedby, Karin E., Hjalgrim, Henrik, Glimelius, Ingrid, Amini, Rose‐Marie, Enblad, Gunilla
Format: Article
Language:English
Subjects:
Cancer och onkologi
CD138 plasma cells
Hematology
Hodgkin's lymphoma
IgG4-producing plasma cells
Immunoglobulin G
Immunohistochemistry
Klinisk laboratoriemedicin
Klinisk medicin
Leukocytes (eosinophilic)
Lymphocytes B
Lymphoma
Medicin och hälsovetenskap
Metastases
Multivariate analysis
Pathology
Patologi
Plasma
Plasma cells
Syndecan-1
Tumors
tumour microenvironment
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Summary:Summary Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti‐CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell‐infiltration was associated with the presence of B‐symptoms (P = 0·028) and advanced stage, IIB‐IVB (P = 0·009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (P = 0·013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (P = 0·004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as ≥10%), had a more inferior event‐free survival (P = 0·007) and overall survival (P = 0·004) than patients with a low proportion of infiltrating CD138+ plasma cells (
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/bjh.15703