Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study

Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities...

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Bibliographic Details
Published in:Environmental health perspectives 2017-05, Vol.125 (5), p.057003
Main Authors: Rahman, Syed Moshfiqur, Kippler, Maria, Tofail, Fahmida, Bölte, Sven, Hamadani, Jena Derakhshani, Vahter, Marie
Format: Article
Language:English
Subjects:
Age
Arsenic
Bangladesh - epidemiology
Behavior
Caregivers
Child
Children
Children & youth
Cognition & reasoning
Cognition - drug effects
Cognitive ability
Cognitive disorders
Cohort analysis
Cohort Studies
Conduct Disorder - chemically induced
Data collection
Drinking water
Drinking Water - adverse effects
Drinking Water - chemistry
Education
Exposure
Families & family life
Female
Fetuses
Girls
Health aspects
Health risk assessment
Humans
Inductively coupled plasma mass spectrometry
Intelligence
Intelligence Tests
Male
Manganese
Manganese - adverse effects
Manganese compounds
Mass spectrometry
Mass spectroscopy
Medicin och hälsovetenskap
Mothers
Neurodevelopment
Pregnancy
Prenatal experience
Prenatal Exposure Delayed Effects - chemically induced
Prospective Studies
Regression analysis
Risk factors
Sex Factors
Studies
Womens health
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Description
Summary:Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior. We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry. The median W-Mn was 0.20 mg/L (range 0.001–6.6) during pregnancy and 0.34mg/L (
ISSN:0091-6765
1552-9924
1552-9924
DOI:10.1289/EHP631