Survival and Late Effects after Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancy at Less than Three Years of Age

Highlights • The 10-year overall survival estimate for those who survived free of relapse ≥1 year after hematopoietic cell transplantation was 87%. • Thirty percent of survivors reported at least 1 late effect • Growth disturbance, cataracts, and hypothyroidism were the most commonly reported late e...

Full description

Saved in:
Bibliographic Details
Published in:Biology of blood and marrow transplantation 2017-08, Vol.23 (8), p.1327-1334
Main Authors: Vrooman, Lynda M, Millard, Heather R, Brazauskas, Ruta, Majhail, Navneet S, Battiwalla, Minoo, Flowers, Mary E, Savani, Bipin N, Akpek, Görgün, Aljurf, Mahmoud, Bajwa, Rajinder, Baker, K. Scott, Beitinjaneh, Amer, Bitan, Menachem, Buchbinder, David, Chow, Eric, Dandoy, Christopher, Dietz, Andrew C, Diller, Lisa, Gale, Robert Peter, Hashmi, Shahrukh K, Hayashi, Robert J, Hematti, Peiman, Kamble, Rammurti T, Kasow, Kimberly A, Kletzel, Morris, Lazarus, Hillard M, Malone, Adriana K, Marks, David I, O'Brien, Tracey A, Olsson, Richard F, Ringden, Olle, Seo, Sachiko, Steinberg, Amir, Yu, Lolie C, Warwick, Anne, Shaw, Bronwen, Duncan, Christine
Format: Article
Language:English
Subjects:
Age Factors
Allografts
Child, Preschool
Chronic Disease
Disease-Free Survival
Female
Follow-Up Studies
Graft vs Host Disease - mortality
Graft vs Host Disease - therapy
Graft-versus-host disease
Hematologic malignancy
Hematologic Neoplasms - mortality
Hematologic Neoplasms - therapy
Hematology, Oncology and Palliative Medicine
Hematopoietic cell transplantation (HCT)
Hematopoietic Stem Cell Transplantation
Humans
Infant
Infants
Late effects
Male
Medicin och hälsovetenskap
Pediatric
Relapse
Survival
Survival Rate
Total body irradiation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • The 10-year overall survival estimate for those who survived free of relapse ≥1 year after hematopoietic cell transplantation was 87%. • Thirty percent of survivors reported at least 1 late effect • Growth disturbance, cataracts, and hypothyroidism were the most commonly reported late effects • Total body irradiation and chronic graft-versus-host-disease were associated with adverse outcomes • Efforts should focus on reducing relapse and late effects after hematopoietic cell transplantation at young age
ISSN:1083-8791
1523-6536
1523-6536
DOI:10.1016/j.bbmt.2017.04.017