Does Beta-Blockade Reduce the Risk of Depression in Patients with Isolated Severe Extracranial Injuries?

Background Approximately half of trauma patients develop post-traumatic depression. It is suggested that beta-blockade impairs trauma memory recollection, reducing depressive symptoms. This study investigates the effect of early beta-blockade on depression following severe traumatic injuries in pati...

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Bibliographic Details
Published in:World journal of surgery 2017-07, Vol.41 (7), p.1801-1806
Main Authors: Ahl, Rebecka, Barmparas, Galinos, Riddez, Louis, Ley, Eric J., Wallin, Göran, Ljungqvist, Olle, Mohseni, Shahin
Format: Article
Language:English
Subjects:
Abbreviate Injury Scale
Abdominal Surgery
Adrenergic beta-Antagonists - therapeutic use
Adult
Aged
Antidepressant Therapy
Antidepressants
Beta blockers
Brain
Brain injury
Cardiac Surgery
Coma
Criteria
Depression - prevention & control
Fatalities
Female
General Surgery
Glasgow Coma Scale
Head injuries
Health risk assessment
Humans
Injuries
Injury analysis
Injury prevention
Injury Severity Score
Kirurgi
Male
Mathematical models
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Mental depression
Middle Aged
Original Scientific Report
Patients
Regression
Retrospective Studies
Reviewing
Risk
Stress Disorders, Post-Traumatic - prevention & control
Surgery
Therapy
Thoracic Surgery
Trauma
Trauma Registry
Vascular Surgery
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Summary:Background Approximately half of trauma patients develop post-traumatic depression. It is suggested that beta-blockade impairs trauma memory recollection, reducing depressive symptoms. This study investigates the effect of early beta-blockade on depression following severe traumatic injuries in patients without significant brain injury. Methods Patients were identified by retrospectively reviewing the trauma registry at an urban university hospital between 2007 and 2011. Severe extracranial injuries were defined as extracranial injuries with Abbreviated Injury Scale score ≥3, intracranial Abbreviated Injury Scale score
ISSN:0364-2313
1432-2323
1432-2323
DOI:10.1007/s00268-017-3935-5