Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis

Objective Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are autoimmune diseases that predominantly affect female patients, and therefore fewer investigations have been conducted in men. The aim of this study was to analyze sex hormone levels in male patients with SLE and those with...

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Bibliographic Details
Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2017-06, Vol.69 (6), p.1272-1279
Main Authors: Arnaud, Laurent, Nordin, Annica, Lundholm, Hannes, Svenungsson, Elisabet, Hellbacher, Erik, Wikner, Johan, Zickert, Agneta, Gunnarsson, Iva
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - adverse effects
Adult
Aged
Androgens
Autoimmune diseases
Biocompatibility
Case-Control Studies
Chronic conditions
Cluster Analysis
Clusters
Corticoids
Corticosteroids
Cross-Sectional Studies
Cyclophosphamide
Cyclophosphamide - adverse effects
Dosage
Dose-Response Relationship, Drug
Fasting
Follicle Stimulating Hormone - blood
Follicle-stimulating hormone
Humans
Hypogonadism
Immunosuppressive Agents - adverse effects
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - drug therapy
Luteinizing hormone
Luteinizing Hormone - blood
Male
Medical personnel
Medicin och hälsovetenskap
Men
Middle Aged
Patients
Physicians
Prednisolone
Prednisolone - adverse effects
Prolactin
Prolactin - blood
Scleroderma
Scleroderma, Systemic - blood
Scleroderma, Systemic - drug therapy
Sex
Supplements
Systemic lupus erythematosus
Systemic sclerosis
Testosterone
Testosterone - blood
Young Adult
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Summary:Objective Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are autoimmune diseases that predominantly affect female patients, and therefore fewer investigations have been conducted in men. The aim of this study was to analyze sex hormone levels in male patients with SLE and those with SSc, compared to matched controls, in relation to the use of corticosteroids and cyclophosphamide (CYC). Methods Sex hormone levels were measured in fasting blood samples from male patients with SLE (n = 71) and those with SSc (n = 29) and compared to population‐based, age‐matched male controls. Relevant hormone profiles were identified using cluster analysis. Results Male SLE patients had higher levels of luteinizing hormone (LH) (P 
ISSN:2326-5191
2326-5205
2326-5205
DOI:10.1002/art.40057