Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants

There is a growing body of evidence that persistent organic pollutants (POPs) may increase the risk for cardiovascular disease (CVD), but the mechanisms remain unclear. High-density lipoprotein (HDL) acts protective against CVD by different processes, and we have earlier found that HDL from subjects...

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Bibliographic Details
Published in:Environment international 2017-01, Vol.98, p.204-211
Main Authors: Ljunggren, Stefan A., Helmfrid, Ingela, Norinder, Ulf, Fredriksson, Mats, Wingren, Gun, Karlsson, Helen, Lindahl, Mats
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aryldialkylphosphatase - blood
Cardiovascular disease
Cardiovascular Diseases - chemically induced
Environmental
Environmental Pollutants - adverse effects
Environmental Pollutants - blood
Female
HDL
Humans
Hydrocarbons, Chlorinated - adverse effects
Hydrocarbons, Chlorinated - blood
Lipoproteins
Lipoproteins, HDL - blood
Male
Medicin och hälsovetenskap
Middle Aged
Persistent organic pollutants
Pesticides - adverse effects
Pesticides - blood
Polychlorinated Biphenyls - adverse effects
Polychlorinated Biphenyls - blood
Proteome
Proteomics
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Summary:There is a growing body of evidence that persistent organic pollutants (POPs) may increase the risk for cardiovascular disease (CVD), but the mechanisms remain unclear. High-density lipoprotein (HDL) acts protective against CVD by different processes, and we have earlier found that HDL from subjects with CVD contains higher levels of POPs than healthy controls. In the present study, we have expanded analyses on the same individuals living in a contaminated community and investigated the relationship between the HDL POP levels and protein composition/function. HDL from 17 subjects was isolated by ultracentrifugation. HDL protein composition, using nanoliquid chromatography tandem mass spectrometry, and antioxidant activity were analyzed. The associations of 16 POPs, including polychlorinated biphenyls (PCBs) and organochlorine pesticides, with HDL proteins/functions were investigated by partial least square and multiple linear regression analysis. Proteomic analyses identified 118 HDL proteins, of which ten were significantly (p
ISSN:0160-4120
1873-6750
1873-6750
DOI:10.1016/j.envint.2016.11.008