Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsutism

Abstract Objective: Hirsutism is the presence of excess terminal hairs in females in a male-like pattern. The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone t...

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Published in:Journal of drug assessment (London, U.K.) U.K.), 2015-01, Vol.4 (1), p.12-18
Main Authors: Tahvilian, Reza, Ebrahimi, Ali, Beiki, Omid, Nemati, Hoshang, Masoud, Sahar
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Language:English
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Finastride
Idiopathic hirsutism
Medicin och hälsovetenskap
Original
Testosterone
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Ebrahimi, Ali
Beiki, Omid
Nemati, Hoshang
Masoud, Sahar
description Abstract Objective: Hirsutism is the presence of excess terminal hairs in females in a male-like pattern. The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone to dihydrotestosterone through inhibition of 5α-reductase in hair follicles. This study was designed to determine the efficacy of finasteride gel 0.25% in management of idiopathic hirsutism and treatment of hirsutism with topical finasteride to lessen the side-effects. Methods: Women after puberty that have idiopathic hirsutism criteria are divided randomly in two groups; treatment and control. The number of patients in each group is 15 and received finasteride and placebo gel once a day on their skins. The patients were visited every month by a dermatologist and the amount of response to the treatment and the patient satisfaction was recorded. Ferriman-Gallwey score of the treated area was determined. Results: After 6-months, mean thickness hairs in treating group were decreased from 102.00 ± 9.58 µm to 86.4 ± 11.4 µm (p 
doi_str_mv 10.3109/21556660.2015.1056525
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The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone to dihydrotestosterone through inhibition of 5α-reductase in hair follicles. This study was designed to determine the efficacy of finasteride gel 0.25% in management of idiopathic hirsutism and treatment of hirsutism with topical finasteride to lessen the side-effects. Methods: Women after puberty that have idiopathic hirsutism criteria are divided randomly in two groups; treatment and control. The number of patients in each group is 15 and received finasteride and placebo gel once a day on their skins. The patients were visited every month by a dermatologist and the amount of response to the treatment and the patient satisfaction was recorded. Ferriman-Gallwey score of the treated area was determined. Results: After 6-months, mean thickness hairs in treating group were decreased from 102.00 ± 9.58 µm to 86.4 ± 11.4 µm (p &lt; 0.05), this difference was statistically significant. Gel application did not indicate any type of side-effects. Limitations: Inclusion and exclusion criteria. Conclusion: Finasteride partially blocks 5α-reductase. Because of the good absorption through the skin and good solubility of this medicine, the prepared gel formulation applied on the hirsutism area showed a significant decrease in hair growth locally, so finasteride gel is an efficient and harmless therapy in patients with idiopathic hirsutism.</description><identifier>ISSN: 2155-6660</identifier><identifier>EISSN: 2155-6660</identifier><identifier>DOI: 10.3109/21556660.2015.1056525</identifier><identifier>PMID: 27536457</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Finastride ; Idiopathic hirsutism ; Medicin och hälsovetenskap ; Original ; Testosterone</subject><ispartof>Journal of drug assessment (London, U.K.), 2015-01, Vol.4 (1), p.12-18</ispartof><rights>2015 All rights reserved: reproduction in whole or part not permitted 2015</rights><rights>2015 Informa UK Ltd 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-be7a32bbab2df4b65fc2ecef5ca40eafef31e2c8738ead2470c32a849342307e3</citedby><cites>FETCH-LOGICAL-c542t-be7a32bbab2df4b65fc2ecef5ca40eafef31e2c8738ead2470c32a849342307e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937630/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937630/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27502,27924,27925,53791,53793,59143,59144,61218,61219</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27536457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:227536457$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Tahvilian, Reza</creatorcontrib><creatorcontrib>Ebrahimi, Ali</creatorcontrib><creatorcontrib>Beiki, Omid</creatorcontrib><creatorcontrib>Nemati, Hoshang</creatorcontrib><creatorcontrib>Masoud, Sahar</creatorcontrib><title>Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsutism</title><title>Journal of drug assessment (London, U.K.)</title><addtitle>J Drug Assess</addtitle><description>Abstract Objective: Hirsutism is the presence of excess terminal hairs in females in a male-like pattern. The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone to dihydrotestosterone through inhibition of 5α-reductase in hair follicles. This study was designed to determine the efficacy of finasteride gel 0.25% in management of idiopathic hirsutism and treatment of hirsutism with topical finasteride to lessen the side-effects. Methods: Women after puberty that have idiopathic hirsutism criteria are divided randomly in two groups; treatment and control. The number of patients in each group is 15 and received finasteride and placebo gel once a day on their skins. The patients were visited every month by a dermatologist and the amount of response to the treatment and the patient satisfaction was recorded. Ferriman-Gallwey score of the treated area was determined. Results: After 6-months, mean thickness hairs in treating group were decreased from 102.00 ± 9.58 µm to 86.4 ± 11.4 µm (p &lt; 0.05), this difference was statistically significant. Gel application did not indicate any type of side-effects. Limitations: Inclusion and exclusion criteria. Conclusion: Finasteride partially blocks 5α-reductase. Because of the good absorption through the skin and good solubility of this medicine, the prepared gel formulation applied on the hirsutism area showed a significant decrease in hair growth locally, so finasteride gel is an efficient and harmless therapy in patients with idiopathic hirsutism.</description><subject>Finastride</subject><subject>Idiopathic hirsutism</subject><subject>Medicin och hälsovetenskap</subject><subject>Original</subject><subject>Testosterone</subject><issn>2155-6660</issn><issn>2155-6660</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><recordid>eNqFUk1v1DAQjRCIVqU_AZQjlyz-iJPshQ9VlCJVggNcsSbOpHFx7GA7rfrvcZTdsnsAfPFo5r03M_bLspeUbDgl2zeMClFVFdkwQsWGElEJJp5kp0u-WApPD-KT7DyEW5LOtqSU1M-zE1YLXpWiPs1-fPU4gYeonc3Bdrky2moFJsc7MPOad31-qS2E6HWH-Q2aXNs8DphHjxBHtHGB6E67CeKgVX6lfZijDuOL7FkPJuD57j7Lvl9-_HZxVVx_-fT54sN1oUTJYtFiDZy1LbSs68u2Er1iqLAXCkqC0GPPKTLV1LxB6FhZE8UZNOWWl4yTGvlZVqy64R6nuZWT1yP4B-lAy13qZ4pQCsIJqxN--1f85F33h7Qnsv2bJe7blZsAI3Yqre_BHEscVawe5I27k2ncuuIkCbzeCXj3a8YQ5aiDQmPAopuDpA1lTZOalQkqVqjyLgSP_WMbSuRiBbm3glysIHdWSLxXhzM-sg6WeL8CtO2dH-HeedPJCA_G-d6DVTos-v_u8e5IYkAwcVDgUd662dv03_-Z8jeyvdsR</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Tahvilian, Reza</creator><creator>Ebrahimi, Ali</creator><creator>Beiki, Omid</creator><creator>Nemati, Hoshang</creator><creator>Masoud, Sahar</creator><general>Informa UK Ltd</general><general>Taylor &amp; Francis</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20150101</creationdate><title>Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsutism</title><author>Tahvilian, Reza ; Ebrahimi, Ali ; Beiki, Omid ; Nemati, Hoshang ; Masoud, Sahar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-be7a32bbab2df4b65fc2ecef5ca40eafef31e2c8738ead2470c32a849342307e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Finastride</topic><topic>Idiopathic hirsutism</topic><topic>Medicin och hälsovetenskap</topic><topic>Original</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tahvilian, Reza</creatorcontrib><creatorcontrib>Ebrahimi, Ali</creatorcontrib><creatorcontrib>Beiki, Omid</creatorcontrib><creatorcontrib>Nemati, Hoshang</creatorcontrib><creatorcontrib>Masoud, Sahar</creatorcontrib><collection>Taylor &amp; Francis Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of drug assessment (London, U.K.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tahvilian, Reza</au><au>Ebrahimi, Ali</au><au>Beiki, Omid</au><au>Nemati, Hoshang</au><au>Masoud, Sahar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsutism</atitle><jtitle>Journal of drug assessment (London, U.K.)</jtitle><addtitle>J Drug Assess</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>4</volume><issue>1</issue><spage>12</spage><epage>18</epage><pages>12-18</pages><issn>2155-6660</issn><eissn>2155-6660</eissn><abstract>Abstract Objective: Hirsutism is the presence of excess terminal hairs in females in a male-like pattern. The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone to dihydrotestosterone through inhibition of 5α-reductase in hair follicles. This study was designed to determine the efficacy of finasteride gel 0.25% in management of idiopathic hirsutism and treatment of hirsutism with topical finasteride to lessen the side-effects. Methods: Women after puberty that have idiopathic hirsutism criteria are divided randomly in two groups; treatment and control. The number of patients in each group is 15 and received finasteride and placebo gel once a day on their skins. The patients were visited every month by a dermatologist and the amount of response to the treatment and the patient satisfaction was recorded. Ferriman-Gallwey score of the treated area was determined. 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subjects Finastride
Idiopathic hirsutism
Medicin och hälsovetenskap
Original
Testosterone
title Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsutism
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