Incidence of Healthcare Associated Infections After Lower Extremity Revascularization Using Antibiotic Treatment as a Marker

Objective/Background This register based study aimed to investigate the rate and pattern of healthcare associated infections (HCAI) in patients treated for lower extremity arterial disease, using antibiotic prescription as a surrogate for post-operative HCAI. Methods A retrospective analysis of pros...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2016-05, Vol.51 (5), p.690-695
Main Authors: Daryapeyma, A, Hammar, U, Wahlgren, C.M
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Antibiotic
Cross Infection - epidemiology
Cross Infection - etiology
Endovascular Procedures - adverse effects
Endovascular Procedures - methods
Female
Healthcare associated infection
Humans
Incidence
Leg - blood supply
Male
Medicin och hälsovetenskap
Middle Aged
Peripheral Arterial Disease - surgery
Registries
Retrospective Studies
Surgery
Surgical Wound Infection - drug therapy
Surgical Wound Infection - epidemiology
Surgical Wound Infection - etiology
Sweden - epidemiology
Vascular
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Summary:Objective/Background This register based study aimed to investigate the rate and pattern of healthcare associated infections (HCAI) in patients treated for lower extremity arterial disease, using antibiotic prescription as a surrogate for post-operative HCAI. Methods A retrospective analysis of prospectively registered data on all patients treated with primary elective, open or endovascular, surgery for lower extremity arterial disease in Sweden between 2005 and 2010, was carried out. Antibiotic prescriptions were determined for three time periods (6 months pre-operative; 30 day post-operative, and 5 months extended post-operative). Results The cohort ( n  = 9894) included patients with claudication (27%, n  = 2659), critical limb ischemia (rest pain without ulceration; 17%, n  = 1681), and ulceration/gangrene (56%, n  = 5552). Fifty-nine percent ( n  = 5865) of the procedures were endovascular interventions. The incidence of 30 day post-operative antibiotic prescriptions was 33% ( n  = 3294). These were comprised of antibiotics for skin and soft tissue infections (67%, n  = 2199); urinary tract infections (UTIs; 21%, n  = 703); and respiratory tract infections (12%, n  = 383). There was a 92% increase in the antibiotic prescription incidence rate for the 1 month post-operative period compared with the pre-operative period ( p  
ISSN:1078-5884
1532-2165
1532-2165
DOI:10.1016/j.ejvs.2015.12.016