Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study

Women who give birth at younger ages (e.g. teenage mothers) are more likely to have children who exhibit behaviour problems, such as attention-deficit/hyperactivity disorder (ADHD). However, it is not clear whether young maternal age is causally associated with poor offspring outcomes or confounded...

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Bibliographic Details
Published in:International journal of epidemiology 2014-12, Vol.43 (6), p.1815-1824
Main Authors: ZHENG CHANG, LICHTENSTEIN, Paul, D'ONOFRIO, Brian M, ALMQVIST, Catarina, KUJA-HALKOLA, Ralf, SJÖLANDER, Arvid, LARSSON, Henrik
Format: Article
Language:English
Subjects:
ADHD
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity - epidemiology
Attention Deficit Disorder with Hyperactivity - genetics
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
Delivery. Postpartum. Lactation
Early Life Exposures
Epidemiology
family-based design
Female
General aspects
Gynecology. Andrology. Obstetrics
Humans
Male
Maternal Age
Medical sciences
Medicin och hälsovetenskap
Miscellaneous
Pregnancy
Pregnancy in Adolescence - statistics & numerical data
Proportional Hazards Models
Public health. Hygiene
Public health. Hygiene-occupational medicine
Siblings - psychology
Sweden - epidemiology
Young Adult
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Summary:Women who give birth at younger ages (e.g. teenage mothers) are more likely to have children who exhibit behaviour problems, such as attention-deficit/hyperactivity disorder (ADHD). However, it is not clear whether young maternal age is causally associated with poor offspring outcomes or confounded by familial factors. The association between early maternal age at childbirth and offspring ADHD was studied using data from Swedish national registers. The sample included all children born in Sweden between 1988 and 2003 (N = 1 495 543), including 30 674 children with ADHD. We used sibling- and cousin-comparisons to control for unmeasured genetic and environmental confounding. Further, we used a children-of-siblings model to quantify the genetic and environmental contribution to the association between maternal age and offspring ADHD. Maternal age at first birth (MAFB) was associated with offspring ADHD. Teenage childbirth (
ISSN:0300-5771
1464-3685
1464-3685
DOI:10.1093/ije/dyu204