Mechanisms of stress, energy homeostasis and insulin resistance in European adolescents – the HELENA study

Abstract Background and aims Stress is hypothesized to facilitate the development of obesity, whose the foundations are already set during childhood and adolescence. We investigated the relationship between the stress-system, selected mechanisms of energy homeostasis and insulin resistance (IR) in a...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-10, Vol.24 (10), p.1082-1089
Main Authors: Huybrechts, I, De Vriendt, T, Breidenassel, C, Rogiers, J, Vanaelst, B, Cuenca-García, M, Moreno, L.A, González-Gross, M, Roccaldo, R, Kafatos, A, Clays, E, Bueno, G, Beghin, L, Sjöstrom, M, Manios, Y, Molnár, D, Pisa, P.T, De Henauw, S
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adolescent
Adolescents
Blood Glucose - metabolism
Body Mass Index
Cardiovascular
Child
Cortisol
Cross-Sectional Studies
Energy homeostasis
Europe
Female
Glucose
HOMA-IR
Homeostasis - physiology
Humans
Hydrocortisone - blood
Insulin
Insulin - blood
Insulin Resistance - physiology
Leptin
Leptin - blood
Male
Medicin och hälsovetenskap
Obesity - blood
Socioeconomic Factors
Stress
Stress, Psychological - blood
White People
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Summary:Abstract Background and aims Stress is hypothesized to facilitate the development of obesity, whose the foundations are already set during childhood and adolescence. We investigated the relationship between the stress-system, selected mechanisms of energy homeostasis and insulin resistance (IR) in a sample of European adolescents. Methods and results Within HELENA-CSS, 723 adolescents (12.5–17.5 years) from 10 European cities provided all the necessary data for this study. Fasting blood samples were collected for cortisol, leptin, insulin and glucose analysis. HOMA-IR was calculated from insulin and glucose concentrations. Adolescents' body fat (BF) %, age and duration of exclusive breastfeeding were assessed. For boys and girls separately, the relationship of cortisol with leptin, insulin, glucose and HOMA-IR was examined by computing Pearson correlation coefficients and Hierarchical Linear Models (HLMs), with ‘city’ as cluster unit, adjusting for age, BF% and duration of exclusive breastfeeding. In boys, Pearson correlation coefficients illustrated positive correlations of cortisol with insulin ( r  = 0.144; p  = 0.013), glucose ( r  = 0.315; p  
ISSN:0939-4753
1590-3729
1590-3729
DOI:10.1016/j.numecd.2014.04.014