Making prospective registration of observational research a reality

The vast majority of health-related observational studies are not prospectively registered and the advantages of registration have not been fully appreciated. Nonetheless, international standards require approval of study protocols by an independent ethics committee before the study can begin. We su...

Full description

Saved in:
Bibliographic Details
Published in:Science translational medicine 2014-02, Vol.6 (224), p.224cm1-224cm1
Main Authors: Dal-Ré, Rafael, Ioannidis, John P, Bracken, Michael B, Buffler, Patricia A, Chan, An-Wen, Franco, Eduardo L, La Vecchia, Carlo, Weiderpass, Elisabete
Format: Article
Language:English
Subjects:
Clinical Protocols
Humans
Medicin och hälsovetenskap
Observational Studies as Topic
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The vast majority of health-related observational studies are not prospectively registered and the advantages of registration have not been fully appreciated. Nonetheless, international standards require approval of study protocols by an independent ethics committee before the study can begin. We suggest that there is an ethical and scientific imperative to publicly preregister key information from newly approved protocols, which should be required by funders. Ultimately, more complete information may be publicly available by disclosing protocols, analysis plans, data sets, and raw data.
ISSN:1946-6234
1946-6242
1946-6242
DOI:10.1126/scitranslmed.3007513