Classification of anaphylaxis and utility of the EAACI Taskforce position paper on Anaphylaxis in Children

• Published in: Pediatric allergy and immunology 2011-06, Vol.22 (4), p.369-373
• Main Authors: Vetander, Mirja, Helander, Daiva, Lindquist, Charlotta, Hedlin, Gunilla, Alfvén, Tobias, Östblom, Eva, Nilsson, Caroline, Lilja, Gunnar, Wickman, Magnus
• Format: Article
• Language: English
• Subjects: Adolescence; Allergic diseases; Anaphylaxis; Anaphylaxis - classification; Biological and medical sciences; Brain; Brain - pathology; Child; Children; Classification; diagnosis; Digestive allergic diseases; Disease Progression; Epinephrine; Epinephrine - therapeutic use; Female; Food; food allergy; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Hospitals; Humans; Hypersensitivity; Hypersensitivity - classification; Hypersensitivity - drug therapy; Hypersensitivity - immunology; Hypersensitivity - physiopathology; Immunopathology; Information Systems; International Classification of Diseases; Male; Medical sciences; Medicin och hälsovetenskap; Pediatrics; Perfusion; Respiratory System - pathology; Respiratory tract; Retrospective Studies; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Severity of Illness Index; Skin - pathology
• ISSN: 0905-6157; 1399-3038; 1399-3038
• DOI: 10.1111/j.1399-3038.2010.01115.x

To cite this article: Vetander M, Helander D, Lindquist C, Hedlin G, Alfvén T, Östblom E, Nilsson C, Lilja G, Wickman M. Classification of anaphylaxis and utility of the EAACI Taskforce position paper on Anaphylaxis in Children.Pediatric Allergy Immunology 2011;: 369–373. Correct management and classification of anaphylaxis is mandatory. Records of emergency department (ED) visits to any of the three pediatric hospitals in Stockholm, because of reactions to foods during 2007, were identified. A retrospective analysis of clinical ED records of 371 children with 381 unique occasions of reactions to foods was performed. Symptoms/signs of reactions to foods recorded for classification of anaphylaxis were related to those presented in the EAACI Taskforce position paper on Anaphylaxis in Children (Allergy 2007; 62: 857). Forty‐six different symptoms/signs of reactions to foods were retrieved. Several severe signs or symptoms from the respiratory tract and signs indicating reduced brain perfusion were not described in detail in the EAACI paper, hampering correct classification of anaphylaxis including grading of severity in our material. After modification of the EAACI classification including such signs and symptoms, we were able to classify 128 (35%) children with anaphylaxis. Seventy children (19%) did not fulfill our modified EAACI’s criteria for anaphylaxis. They had been given adrenaline before or at arrival to hospital, possibly preventing anaphylaxis. Another 173 (47%) children/adolescents had neither been given adrenalin, nor fulfilled the criteria for anaphylaxis. Classification of food‐induced anaphylaxis and severity grading should be built on signs and symptoms to facilitate diagnosis. The existing EAACI tool is helpful, but for Swedish children it is not quite applicable, in particular because of the lack of description of some respiratory, neurological or possible cardiovascular signs and symptoms.