Factor V Leiden mutation and pregnancy-related complications

Objective The objective of the study was to determine the prevalence of the factor V Leiden (FVL) mutation and its association with obstetric complications, blood loss during delivery, and venous thromboembolism (VTE). Study Design This was a prospective, observational, case-cohort study of 491 FVL...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2010, Vol.203 (5), p.469.e1-469.e8
Main Authors: Kjellberg, Ulla, MD, PhD, van Rooijen, Marianne, MD, PhD, Bremme, Katarina, MD, PhD, Hellgren, Margareta, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
blood loss
Case-Control Studies
Factor V
Factor V - genetics
factor V Leiden
Female
genetics
Genotype
Gynecology. Andrology. Obstetrics
Hematologic
Humans
Hypertension
Hypertension, Pregnancy-Induced - genetics
Medical sciences
Medicin och hälsovetenskap
Mutation
obstetric complications
Obstetrics and Gynecology
Obstetrics, Gynecology and Reproductive Medicine
Pregnancy
Pregnancy Complications
Pregnancy Complications, Hematologic - genetics
Pregnancy-Induced
Prevalence
Prospective Studies
Reproduktionsmedicin och gynekologi
Risk Factors
Thrombophilia
Thrombophilia - genetics
Venous Thromboembolism
Venous Thromboembolism - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The objective of the study was to determine the prevalence of the factor V Leiden (FVL) mutation and its association with obstetric complications, blood loss during delivery, and venous thromboembolism (VTE). Study Design This was a prospective, observational, case-cohort study of 491 FVL carriers and 1055 controls derived from 6003 screened women. Data were analyzed with a Student t test and cross-tabulation. Results FVL carriership prevalence was 8.3%. Gestational age at delivery, birthweight deviation, gestational hypertension, and preeclampsia incidences did not differ between groups. The incidences of placental abruption, neonatal asphyxia, eclampsia, intrauterine fetal death, intrapartum death, and unexplained late miscarriage were low. The incidence of major blood loss at delivery was lower in carriers. There were 3 VTEs among carriers and none among controls. Conclusion FVL carriership did not influence pregnancy-induced hypertension, birthweight, or prematurity but raised the risk of venous thromboembolism and lowered the risk of major blood loss.
ISSN:0002-9378
1097-6868
1097-6868
DOI:10.1016/j.ajog.2010.08.011