A randomized study of buffy coat platelets in platelet additive solution stored 1-5 versus 6-7 days prior to prophylactic transfusion of allogeneic haematopoietic progenitor cell transplant recipients

Background and Objective  Storage of platelets > 5 days provides improved availability, logistical management and decreased outdating. Promising results on in vitro parameters and on in vivo post‐transfusion recovery and survival of autologous platelets in healthy volunteers have earlier been sho...

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Bibliographic Details
Published in:Vox sanguinis 2009-10, Vol.97 (3), p.254-259
Main Authors: Diedrich, B., Ringdén, O., Watz, E., Shanwell, A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Blood Platelets - drug effects
Blood Preservation - methods
Blood Preservation - statistics & numerical data
Blood transfusions
Clinical outcomes
Clinical trials
corrected count increment
Female
Hematopoietic Stem Cell Transplantation - statistics & numerical data
Humans
Male
Medicin och hälsovetenskap
Middle Aged
Neoplasms - blood
Neoplasms - surgery
Pharmaceutical Solutions - pharmacology
Platelet storage
platelet transfusion
Platelet Transfusion - methods
platelets
Postoperative Care
Postoperative Complications - therapy
Postoperative Hemorrhage - epidemiology
Postoperative Hemorrhage - etiology
Postoperative Hemorrhage - prevention & control
Storage
Thrombocytopenia - complications
Thrombocytopenia - therapy
Time Factors
Transplantation, Homologous
Young Adult
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Summary:Background and Objective  Storage of platelets > 5 days provides improved availability, logistical management and decreased outdating. Promising results on in vitro parameters and on in vivo post‐transfusion recovery and survival of autologous platelets in healthy volunteers have earlier been shown. To provide additional verification, randomized patient transfusion studies are needed. Materials and Methods  Sixty allogeneic haematopoietic progenitor cell transplant recipients were randomized to receive buffy‐coat (BC) platelets stored in platelet additive solution (PAS) for 1–5 days the first time a prophylactic transfusion was needed after transplantation, followed the second time by platelets stored for 6–7 days or vice versa. The corrected count increment (CCI) for 1 and 24 h were calculated. Results  CCI 1 h and CCI 24 h were higher for platelets stored 1–5 days as compared to 6–7 days, 10·4 ± 5·1 vs. 7·4 ± 3·8 (P 
ISSN:0042-9007
1423-0410
1423-0410
DOI:10.1111/j.1423-0410.2009.01197.x