Inverse association of high‐fat diet preference and anxiety‐like behavior: a putative role for urocortin 2

The aim of this study was to investigate whether the preference for a palatable high‐fat diet (HFD) is associated with response to novelty and with anxiety‐like behavior in rats and whether such fat preference correlates with gene expression of hypothalamic neuropeptides related to feeding. We subje...

Full description

Saved in:
Bibliographic Details
Published in:Genes, brain and behavior brain and behavior, 2009-03, Vol.8 (2), p.193-202
Main Authors: Alsiö, J., Roman, E., Olszewski, P. K., Jonsson, P., Fredriksson, R., Levine, A. S., Meyerson, B. J., Hulting, A.‐L., Lindblom, J., Schiöth, H. B.
Format: Article
Language:English
Subjects:
Animals
Anxiety
Anxiety - psychology
corticotropin-releasing factor receptor
dietary fat
Dietary Fats
DNA, Complementary - biosynthesis
DNA, Complementary - genetics
Eating - genetics
Eating - physiology
elevated plus maze
Emotions - physiology
exploratory behavior
Exploratory Behavior - physiology
Farmaceutisk farmakologi
FARMACI
Farmakologisk forskning
food preferences
Food Preferences - physiology
Fysiologi och farmakologi
Gene Expression
Hormones - blood
Hypothalamus - metabolism
Individuality
Male
MEDICIN
Medicin och hälsovetenskap
MEDICINE
multivariate concentric square field
novelty seeking
palatable
Pharmaceutical pharmacology
Pharmacological research
PHARMACY
Physiology and pharmacology
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
urocortin 2
Urocortins - genetics
Urocortins - physiology
Weight Gain - genetics
Weight Gain - physiology
Wistar
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to investigate whether the preference for a palatable high‐fat diet (HFD) is associated with response to novelty and with anxiety‐like behavior in rats and whether such fat preference correlates with gene expression of hypothalamic neuropeptides related to feeding. We subjected male rats to two tests of exploration of novel environments: the multivariate concentric square field (MCSF) and the elevated plus maze (EPM). The rats were then exposed to a 5‐day test of preference for a palatable HFD versus reference diets. Messenger RNA (mRNA) levels of 21 neuropeptides were investigated by quantitative polymerase chain reaction. We found a strong positive correlation of HFD preference and open‐arm activity in the EPM (% open‐arm time, rs = 0.629, df = 26, P 
ISSN:1601-1848
1601-183X
1601-183X
DOI:10.1111/j.1601-183X.2008.00464.x