Difference in Cell Proliferation between Two Structurally Different Lesions in Colorectal Adenomas: High-grade Dysplasia and Carcinoma In Situ

• Published in: Anticancer research 2007-11, Vol.27 (6C), p.4321-4324
• Main Author: RUBIO, C. A
• Format: Article
• Language: English
• Subjects: Adenoma - classification; Adenoma - metabolism; Adenoma - pathology; Aged; Biological and medical sciences; Carcinoma in Situ - classification; Carcinoma in Situ - metabolism; Carcinoma in Situ - pathology; Cell Proliferation; Colorectal Neoplasms - classification; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Diagnosis, Differential; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Ki-67 Antigen - metabolism; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Precancerous Conditions - classification; Precancerous Conditions - metabolism; Precancerous Conditions - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors
• ISSN: 0250-7005; 1791-7530

Background: Despite the fact that most Western pathologists diagnose carcinoma in situ (CIS) in many organs the same pathologists generally diagnose similar histological aberrations in colorectal adenomas, as high-grade dysplasia (HGD). Materials and Methods: Five large colorectal adenomas (measuring ≥20 mm) having areas of both HGD and CIS on staining with hematoxylin and eosin (H&E) were assessed with the proliferation antibody Ki-67 (clone MIB1). Results: HGD is built of tightly packed, spindle shaped, hyperchromatic cells with moderate pleomorphic nuclei having coarse chromatin and CIS of marked pleomorphic, vesicular, hypochromatic nuclei with a prominent nucleolus. Ki-67 was expressed in 96% of the HGD cells but only in 3.5% of the CIS cells (p