Distribution and morphology of putative catecholaminergic and serotonergic neurons in the brain of the greater canerat, Thryonomys swinderianus

• Published in: Journal of chemical neuroanatomy 2008, Vol.35 (1), p.108-122
• Main Authors: Dwarika, Sarika, Maseko, Busisiwe C., Ihunwo, Amadi O., Fuxe, Kjell, Manger, Paul R.
• Format: Article
• Language: English
• Subjects: Animals; Brain - cytology; Brain - metabolism; Brain Mapping; Catecholamines - metabolism; Cell Shape - physiology; Dendrites - metabolism; Dendrites - ultrastructure; Evolution; Immunohistochemistry; Mammal; Medicin och hälsovetenskap; Neural systems; Neurons - cytology; Neurons - metabolism; Phylogeny; Raphe Nuclei - cytology; Raphe Nuclei - metabolism; Reticular Formation - cytology; Reticular Formation - metabolism; Rodent; Rodentia; Rodentia - anatomy & histology; Rodentia - metabolism; Serotonin; Serotonin - metabolism; Species Specificity; Synaptic Transmission - physiology; Thryonomys swinderianus; Tyrosine 3-Monooxygenase - metabolism; Tyrosine hydroxylase
• ISSN: 0891-0618; 1873-6300
• DOI: 10.1016/j.jchemneu.2007.08.005

The distribution, morphology and nuclear subdivisions of the putative catecholaminergic and serotonergic systems within the brain of the greater canerat (sometimes spelt cane rat) were identified following immunohistochemistry for tyrosine hydroxylase and serotonin. The aim of the present study was to investigate possible differences in the complement of nuclear subdivisions of these systems when comparing those of the greater canerat with reports of these systems in other rodents. The greater canerat was chosen for investigation as it is a large rodent (around 2.7 kg body mass) and has an average brain mass of 13.75 g, more than five times larger than that of the laboratory rat. The greater canerats used in the present study were caught from the wild, which is again another contrast to the laboratory rat. While these differences, especially that of size, may lead to the prediction of significant differences in the nuclear complement of these systems, we found that all nuclei identified in both systems in the laboratory rat and other rodents in several earlier studies had direct homologs in the brain of the greater canerat. Moreover, there were no additional nuclei in the brain of the greater canerat that are not found in the laboratory rat or other rodents. It is noted that the locus coeruleus of the laboratory rat differs in appearance to that reported for several other rodent species. The greater canerat is phylogenetically distant from the laboratory rat, but still a member of the order Rodentia. Thus, changes in the nuclear organization of these systems appears to demonstrate a form of constraint related to the phylogenetic level of the order.