Associations between Androgen and Vitamin D Receptor Microsatellites and Postmenopausal Breast Cancer

We investigated the association between polymorphism in the androgen receptor ( AR ) and vitamin D receptor ( VDR ) genes and breast cancer risk in a large population-based case-control study of genetically homogenous Swedish women. We successfully determined both AR CAG n and VDR A n genotype in 1,...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-09, Vol.16 (9), p.1775-1783
Main Authors: WEDREN, Sara, MAGNUSSON, Cecilia, HUMPHREYS, Keith, MELHUS, Hakan, KINDMARK, Andreas, STIGER, Fredrik, BRANTING, Maria, PERSSON, Ingemar, BARON, John, WEIDERPASS, Elisabete
Format: Article
Language:English
Subjects:
Aged
Alleles
androgen receptor
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
MEDICIN
Medicin och hälsovetenskap
MEDICINE
Microsatellite Repeats - genetics
Middle Aged
molecular epidemiology
polymorphism
Polymorphism, Single Nucleotide
Postmenopause
Receptors, Androgen - genetics
Receptors, Calcitriol - genetics
Risk
Risk Factors
Sweden
Tumors
vitamin D receptor
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Summary:We investigated the association between polymorphism in the androgen receptor ( AR ) and vitamin D receptor ( VDR ) genes and breast cancer risk in a large population-based case-control study of genetically homogenous Swedish women. We successfully determined both AR CAG n and VDR A n genotype in 1,502 women with invasive breast cancer and in 1,510 control women. We did not find any associations between AR or VDR microsatellite lengths and breast cancer when we used a priori determined cutoffs (≤21 or ≥22 repeats for AR and ≤18 or ≥19 for VDR ) to define long and short alleles. There was statistically significant interaction between VDR genotype and parity, such that women with two short alleles had a halved risk for breast cancer, irrespective of parity, compared with nulliparous women with two long alleles. Homozygosity for the long VDR allele was associated with a more advanced clinical stage at diagnosis. In exploratory analyses, we determined cutoffs based on visual inspection of distributions of allele lengths among cases and controls and found that women carrying two alleles with
ISSN:1055-9965
1538-7755
1538-7755
DOI:10.1158/1055-9965.EPI-06-1096