Familial aggregation of small-for-gestational-age births: The importance of fetal genetic effects

This study was undertaken to disentangle the maternal genetic, fetal genetic, and environmental effects for the risk of having small-for-gestational-age (SGA) offspring. By cross-linking the population-based Swedish Multi-Generation and Medical Birth Registers, we extracted 2,193,142 births between...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2006-02, Vol.194 (2), p.475-479
Main Authors: Svensson, Anna C., Pawitan, Yudi, Cnattingius, Sven, Reilly, Marie, Lichtenstein, Paul
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Environment
Familial risk
Female
Fetal Growth Retardation - genetics
Fetus - physiopathology
Genes
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Infant, Small for Gestational Age
Linear Models
Medical sciences
Medicin och hälsovetenskap
Odds Ratio
Pregnancy
Pregnancy. Fetus. Placenta
Registries
Risk Factors
Siblings
Small for gestational age
Smoking - epidemiology
Sweden - epidemiology
Uterus - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was undertaken to disentangle the maternal genetic, fetal genetic, and environmental effects for the risk of having small-for-gestational-age (SGA) offspring. By cross-linking the population-based Swedish Multi-Generation and Medical Birth Registers, we extracted 2,193,142 births between 1973 and 2001 with both parents identified. Odds ratios (OR) were calculated to estimate the relative risks, and generalized linear mixed models were used to estimate the contribution of genetic and environmental effects. Women whose full sisters had an offspring born SGA had a significantly increased risk of having a SGA offspring themselves (OR = 1.8, 95% CI 1.7-1.9), whereas the corresponding risk for brothers was lower (OR = 1.3, 95% CI 1.2-1.4). Thirty-seven percent of the liability was explained by fetal (including both maternal and paternal) genetic effects and 9% by maternal genetic effects. Genetic factors account for almost half of the liability to have SGA births. These effects are primarily caused by fetal genes.
ISSN:0002-9378
1097-6868
1097-6868
DOI:10.1016/j.ajog.2005.08.019