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Incidence Trends of Adenocarcinoma of the Cervix in 13 European Countries
Rapid increases in cervical adenocarcinoma incidence have been observed in Western countries in recent decades. Postulated explanations include an increasing specificity of subtype—the capability to diagnose the disease, an inability of cytologic screening to reduce adenocarcinoma, and heterogeneity...
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Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-09, Vol.14 (9), p.2191-2199 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Rapid increases in cervical adenocarcinoma incidence have been observed in Western countries in recent decades. Postulated
explanations include an increasing specificity of subtype—the capability to diagnose the disease, an inability of cytologic
screening to reduce adenocarcinoma, and heterogeneity in cofactors related to persistent human papillomavirus infection. This
study examines the possible contribution of these factors in relation with trends observed in Europe. Age-period-cohort models
were fitted to cervical adenocarcinoma incidence trends in women ages 30. Whereas increasing specificity of subtype
with time may be responsible for some of the increases in several countries, the changing distribution and prevalence of persistent
infection with high-risk human papillomavirus types, alongside an inability to detect cervical adenocarcinoma within screening
programs, would accord with the temporal profile observed in Europe. The homogeneity of trends in adenocarcinoma and squamous
cell carcinoma in birth cohort is consistent with the notion that they share a similar etiology irrespective of the differential
capability of screen detection. Screening may have had at least some impact in reducing cervical adenocarcinoma incidence
in several countries during the 1990s. |
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ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.EPI-05-0231 |