Passive IgE‐sensitization by blood transfusion

Background:  To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen. Methods:  When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibo...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2005-09, Vol.60 (9), p.1192-1199
Main Authors: Johansson, S. G. O., Nopp, A., Hage, M., Olofsson, N., Lundahl, J., Wehlin, L., Söderström, L., Stiller, V., Öman, H.
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergic diseases
allergy
basophils
Basophils - immunology
Biological and medical sciences
Blood Transfusion
CD63
Conjunctivitis, Allergic - immunology
flow cytometry
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
IgE antibody
Immunization, Passive
Immunoglobulin E - immunology
Immunologic Tests
Immunopathology
Mast Cells - immunology
Medical sciences
Medicin och hälsovetenskap
Phleum - immunology
Respiratory Hypersensitivity - immunology
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Summary:Background:  To study the mechanisms of passive sensitization of patients receiving plasma containing IgE antibodies to a defined allergen. Methods:  When required for medical reasons, regular donor plasma with IgE antibodies to timothy grass allergen (8–205 kUA/l), was given. Kinetics of IgE antibodies in the recipients’ serum and his/her basophil allergen threshold sensitivity, CD‐sens, was monitored up to 2–3 weeks after transfusion. The IgE antibodies were quantitated by ImmunoCAP. The CD‐sens in plasma recipients, determined by CD63 up‐regulation, was measured by flow cytometry and compared to CD‐sens of patients with allergic asthma and/or rhinitis. Results:  There was a significant correlation (r = 0.98; P 
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2005.00870.x