Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age

The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ( n=45) from a previously published cross-secti...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2005-08, Vol.30 (7), p.625-637
Main Authors: Wahlin, Åke, Bunce, David, Wahlin, Tarja-Brita Robins
Format: Article
Language:English
Subjects:
Affect - physiology
Aged - physiology
Aged - psychology
Aged, 80 and over
Behavioral psychophysiology
Biological and medical sciences
Cognition - physiology
Cognitive function
Cross-Sectional Studies
Death
Episodic memory
Female
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Humans
Longitudinal
Longitudinal Studies
Male
Medicin och hälsovetenskap
Memory - physiology
Neuropsychological Tests
Old age
Psychology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychomotor Performance - physiology
Psykologi
SAMHÄLLSVETENSKAP
SOCIAL SCIENCES
Socialvetenskap
Space Perception - physiology
Sweden
Thyroid function
Thyrotropin - physiology
Thyroxine - blood
Triiodothyronine - blood
TSH
Verbal Behavior
Visual Perception - physiology
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Summary:The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ( n=45) from a previously published cross-sectional study. Participants were aged 75–93 years at baseline, and data reported were collected in the Kungsholmen Project, a longitudinal project investigating aging and dementia. Analyses revealed that although declining verbal fluency and visuospatial abilities were accompanied by simultaneously declining TSH levels, the pattern of cross-sectional and longitudinal results are interpreted such that declining TSH levels may have caused episodic memory deficits later on. These results were obtained in the examination of 6-year but not 3-year change, and after removal of the cognitive variation associated with depressive mood symptoms.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2005.01.010