Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women

Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2004-10, Vol.29 (9), p.1138-1141
Main Authors: Ho, Hoi-Por, Westberg, Lars, Annerbrink, Kristina, Olsson, Marie, Melke, Jonas, Nilsson, Staffan, Baghaei, Fariba, Rosmond, Roland, Holm, Göran, Björntorp, Per, Andersch, Sven, Allgulander, Christer, Eriksson, Elias
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety
Anxiety disorders. Neuroses
Biological and medical sciences
Chromosomes
Chromosomes, Human, Pair 11 - genetics
Female
Gene Frequency
Genetic
Genetic Predisposition to Disease
genetics
Human
Humans
Male
MEDICAL AND HEALTH SCIENCES
Medical sciences
MEDICIN OCH HÄLSOVETENSKAP
Pair 11
Panic Disorder
Panic Disorder - genetics
Polymorphism
Polymorphism, Single Nucleotide - genetics
Progesterone
Progesterone receptor
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors
Receptors, Progesterone - genetics
Respiration
Risk Factors
Sex Factors
Single Nucleotide
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Summary:Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls ( p=0.01). When male and female patients were analyzed separately, the association was observed in female patients only ( p=0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2004.01.005