Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release

This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz...

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Bibliographic Details
Published in:Brain research 2001-03, Vol.896 (1), p.183-187
Main Authors: Tanaka, Satoshi, Barron, Kirk W., Chandler, Margaret J., Linderoth, Bengt, Foreman, Robert D.
Format: Article
Language:English
Subjects:
Animals
Antidromic afferent activation
Biological and medical sciences
Blood Pressure - physiology
Calcitonin gene-related peptide
Calcitonin Gene-Related Peptide - metabolism
Calcitonin Gene-Related Peptide - pharmacology
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Ganglionic Blockers - pharmacology
Heart Rate - physiology
Hexamethonium - pharmacology
Male
Medicin och hälsovetenskap
Neurons, Afferent - metabolism
Peptide Fragments - metabolism
Peptide Fragments - pharmacology
Rats
Rats, Sprague-Dawley
Skin - blood supply
Skin vasodilation
Spinal Cord - physiology
Spinal cord stimulation
Sympathetic inhibition
Sympathetic Nervous System - physiology
Vasodilation - drug effects
Vasodilation - physiology
Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Summary:This study examined whether spinal cord stimulation (SCS) at intensities below motor threshold (MT) produces cutaneous vasodilation through sympathetic inhibition and/or antidromic activation of sensory fibers. SCS was applied to anesthetized rats with stimulus parameters used clinically, i.e. 50 Hz, 0.2 ms and stimulus intensities at 30, 60 or 90% of MT. SCS-induced vasodilation was not attenuated by hexamethonium, an autonomic ganglion blocking agent, but was abolished by CGRP-(8–37), an antagonist of the calcitonin gene-related peptide (CGRP) receptor. We concluded that SCS-induced vasodilation under the conditions of this study was mediated by peripheral release of CGRP via antidromic activation of sensory fibers.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02144-8