Density profiles of Alzheimer disease regional brain pathology for the Huddinge brain bank: pattern recognition emulates and expands upon Braak staging

Density profiles of Alzheimer's disease (AD) regional brain pathology were constructed for 249 subjects in the Huddinge Brain Bank. Counts per square millimeter for neurofibrillary tangles (NFT), diffuse plaques (DP), and neuritic plaques (NP) in 38 areas were investigated using a pattern recog...

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Bibliographic Details
Published in:Experimental gerontology 2000-09, Vol.35 (6), p.851-864
Main Authors: Corder, E.H, Woodbury, M.A, Volkmann, I, Madsen, D.K, Bogdanovic, N, Winblad, B
Format: Article
Language:English
Subjects:
Alzheimer Disease - pathology
Alzheimer's disease
Brain - pathology
Dementia
Diffuse plaque
Fuzzy logic
Grade-of membership analysis
Humans
Latent class analysis
Medicin och hälsovetenskap
Neurites - pathology
Neuritic plaque
Neurofibrillary tangles
Neurofibrillary Tangles - pathology
Organ Size
Pattern recognition
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Summary:Density profiles of Alzheimer's disease (AD) regional brain pathology were constructed for 249 subjects in the Huddinge Brain Bank. Counts per square millimeter for neurofibrillary tangles (NFT), diffuse plaques (DP), and neuritic plaques (NP) in 38 areas were investigated using a pattern recognition technique called GoM. The seven distributional profiles of AD neuropathology emulated and expanded upon Braak staging illustrating induction (Groups 1–3) and clinical progression (Groups 4–7). Normal aging represented limited AD changes, few NFT in the entorhinal cortex and hippocampal CA1 (Group 1). The threshold for possible AD was NFT in the subiculum (Group 2), found with DP in the neocortex. Temporal medial NFT was the threshold for probable AD (Group 4). The ‘oldest-old’, often demented without brain atrophy, had extensive entorhinal/CA1 NFT and cortical DP, but few cortical NFT or NP (Group 5). A second subtype ‘disconnection’ (Group 6) lacked AD pathology for a specific set of subcortical and cortical areas. Accumulation of NFT in first-affected areas continued through end-stage disease (Group 7), with apparent rapid transition of DP to NP in the cortex during clinical progression. The evolution of AD is a highly ordered sequential process. Pattern recognition approaches such as GoM may be useful in better defining the process.
ISSN:0531-5565
1873-6815
DOI:10.1016/S0531-5565(00)00147-9