Serum urate determines antioxidant capacity in middle‐aged men – a controlled, randomized diet and exercise intervention study

Rosell M, Regnström J, Kallner A, Hellénius M‐L (Karolinska Hospital and Karolinska Institute, Stockholm, Sweden). Serum urate determines antioxidant capacity in middle‐aged men – a controlled, randomized diet and exercise intervention study. J Intern Med 1999; 246: 219–226. Objectives. To study whe...

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Published in:Journal of internal medicine 1999-08, Vol.246 (2), p.219-226
Main Authors: Rosell, M., Regnström, J., Kallner, A., Hellénius, M.‐L.
Format: Article
Language:English
Subjects:
Adult
antioxidant capacity
antioxidant intake
Antioxidants - metabolism
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Constitution
Body Mass Index
Cardiology. Vascular system
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Cholesterol - blood
Diet
Exercise
Humans
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Triglycerides - blood
uric acid
Uric Acid - blood
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Summary:Rosell M, Regnström J, Kallner A, Hellénius M‐L (Karolinska Hospital and Karolinska Institute, Stockholm, Sweden). Serum urate determines antioxidant capacity in middle‐aged men – a controlled, randomized diet and exercise intervention study. J Intern Med 1999; 246: 219–226. Objectives. To study whether advice on diet and/or exercise, given in order to reduce cardiovascular risk factors in middle‐aged men, affects the intake of antioxidants, urate concentration and the total antioxidant capacity in serum. Design. A 6‐month randomized controlled intervention study. Setting. Primary Health Care in Sollentuna, Stockholm, and the Department of Medicine, Karolinska Hospital, Stockholm, Sweden. Subjects. One hundred and fifty‐eight healthy men (46.2 ± 5.0 years) with moderately raised cardiovascular risk factors. Interventions. Advice on diet (D, n = 40), exercise (E, n = 39), diet and exercise (DE, n = 39) and a control group (C, n = 39). Main outcome measures. Dietary intake, exercise habits, S‐urate and the antioxidant capacity in serum (TAOC). Results. After 6 months, changes in dietary and exercise habits were seen in all three intervention groups and favourable effects were seen on BMI, waist circumference, blood pressure, S‐cholesterol and fasting insulin. The intake of α‐tocopherol was decreased in groups D and E (P 
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.1999.00522.x