Genetic link to cervical tumours

Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives...

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Bibliographic Details
Published in:Nature (London) 1999-07, Vol.400 (6739), p.29-30
Main Authors: Magnusson, Patrik K. E, Sparén, Pär, Gyllensten, Ulf B
Format: Article
Language:English
Subjects:
Age of Onset
Female
Genetic Predisposition to Disease
Human papillomavirus
Humanities and Social Sciences
Humans
Infectious Disease Transmission, Vertical
Medicin och hälsovetenskap
multidisciplinary
Papillomaviridae
Papillomavirus Infections - transmission
Registries
Risk Assessment
Science
Science (multidisciplinary)
scientific-correspondence
Sweden - epidemiology
Tumor Virus Infections - transmission
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - virology
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Summary:Cervical cancer is strongly associated with infection by oncogenic types of human papilloma virus (HPV). But only a small fraction of those infected develop cancer, indicating that other factors contribute to the progression to cervical cancer. We have compared incidence of the disease in relatives of cases of cervical tumour and controls, and find a significant familial clustering among biological, but not adoptive, relatives. We find no difference in the risk to siblings who have a mother or father in common, so the clustering cannot be explained by vertical transmission of HPV from mother to child. These results provide epidemiological evidence of a genetic predisposition to cervical cancer.
ISSN:0028-0836
1476-4687
DOI:10.1038/21801