Antibacterial peptide from H. pylori

Colonization of the human stomach by the bacterium Helicobacter pylori is a predisposing factor for gastrointestinal illnesses such as gastritis and peptic ulcers 1 . But most infections are asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial effects on infec...

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Bibliographic Details
Published in:Nature (London) 1999-04, Vol.398 (6729), p.671-672
Main Authors: Pütsep, Katrin, Brändén, Carl-Ivar, Boman, Hans G., Normark, Staffan
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacillus megaterium - drug effects
Bacterial Proteins - chemistry
Bacterial Proteins - isolation & purification
Bacterial Proteins - pharmacology
Escherichia coli - drug effects
Helicobacter Infections
Helicobacter pylori
Helicobacter pylori - chemistry
Humanities and Social Sciences
Humans
multidisciplinary
Peptides
Ribosomal Proteins - isolation & purification
Science
Science (multidisciplinary)
scientific-correspondence
Stomach - microbiology
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Summary:Colonization of the human stomach by the bacterium Helicobacter pylori is a predisposing factor for gastrointestinal illnesses such as gastritis and peptic ulcers 1 . But most infections are asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial effects on infected carriers who are heavily exposed to other gastrointestinal pathogens 2 . We find that H. pylori possesses antibacterial activity to which it is itself resistant. We have traced this activity to cecropin-like amino-terminal peptides derived from the ribosomal protein L1 (RpL1).
ISSN:0028-0836
1476-4687
DOI:10.1038/19439