Epigenome‐wide analysis of frailty: Results from two European twin cohorts

Epigenetics plays an important role in the aging process, but it is unclear whether epigenetic factors also influence frailty, an age‐related state of physiological decline. In this study, we performed a meta‐analysis of epigenome‐wide association studies in four samples drawn from the Swedish Adopt...

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Bibliographic Details
Published in:Aging cell 2024-06, Vol.23 (6), p.e14135-n/a
Main Authors: Mak, Jonathan K. L., Skovgaard, Asmus Cosmos, Nygaard, Marianne, Kananen, Laura, Reynolds, Chandra A., Wang, Yunzhang, Kuja‐Halkola, Ralf, Karlsson, Ida K., Pedersen, Nancy L., Hägg, Sara, Soerensen, Mette, Jylhävä, Juulia
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Aging
Aging - genetics
Alzheimer's disease
Blood
Cohort Studies
CpG islands
CpG Islands - genetics
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic
Epigenetics
Epigenome - genetics
Female
Frailty
Frailty - genetics
Genome-Wide Association Study
Genomes
Humans
Longitudinal Studies
Main Issue
Male
Medicin och hälsovetenskap
Meta-analysis
Sex chromosomes
Twin studies
Twins
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Summary:Epigenetics plays an important role in the aging process, but it is unclear whether epigenetic factors also influence frailty, an age‐related state of physiological decline. In this study, we performed a meta‐analysis of epigenome‐wide association studies in four samples drawn from the Swedish Adoption/Twin Study of Aging (SATSA) and the Longitudinal Study of Aging Danish Twins (LSADT) to explore the association between DNA methylation and frailty. Frailty was defined using the frailty index (FI), and DNA methylation levels were measured in whole blood using Illumina's Infinium HumanMethylation450K and MethylationEPIC arrays. In the meta‐analysis consisting of a total of 829 participants, we identified 589 CpG sites that were statistically significantly associated with either the continuous or categorical FI (false discovery rate 
ISSN:1474-9718
1474-9726
1474-9726
DOI:10.1111/acel.14135